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首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats.
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Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats.

机译：从沙棘沙棘种子残留物中提取的总黄酮对蔗糖喂养大鼠的降压作用。

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The study was designed to investigate the antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. (TFH-SR) and its underlying mechanism in chronic sucrose-fed rats by evaluating its ability to regulate insulin and angiotensin || levels. Feeding of high-sucrose diet (HS: 77% of kcal from carbohydrate, 16% from protein and 6% from lipid, respectively) for 6 weeks resulted in significant rise in systolic blood pressure (SBP) by 25.60%, plasma insulin by 114.24%, triglycerides by 85.14% and activated angiotensin || contents in heart and kidney. However, TFH-SR treatment significantly suppressed the elevated hypertension, hyperinsulinemia and dyslipidemia. Furthermore, TFH-SR (especially at the dose of 150mg/kg/day) increased the circulatory blood angiotensin || level as effective as angiotensin || receptor blocker. These results indicated that TFH-SR exerted its antihypertensive effects at least in part by improving insulin sensitivity and blocking angiotensin || signal pathway. Findings of the present study suggested that TFH-SR might prove to be of potential use in the management of hyperinsulinemia in non-diabetic state with cardiovascular diseases.
机译：该研究旨在通过评估沙棘沙棘种子（TFH-SR）的总黄酮对慢性蔗糖喂养大鼠的降压作用及其潜在机制来研究其调节胰岛素和血管紧张素的能力。水平。高蔗糖饮食（HS：分别来自碳水化合物的大卡的77％，蛋白质的16％和脂质的6％的大卡）分别导致收缩压（SBP）显着升高25.60％，血浆胰岛素114.24升高。 ％，甘油三酸酯占85.14％，活化的血管紧张素||在心脏和肾脏中的含量。但是，TFH-SR治疗可显着抑制高血压，高胰岛素血症和血脂异常。此外，TFH-SR（尤其是在150mg / kg /天的剂量下）可增加循环血血管紧张素水平与血管紧张素||一样有效受体阻滞剂。这些结果表明，TFH-SR至少部分通过改善胰岛素敏感性和阻断血管紧张素发挥其降压作用。信号通路。本研究的发现表明，TFH-SR可能被证明可用于非糖尿病合并心血管疾病的高胰岛素血症的治疗。

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