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首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Pharmacodynamic screening and simulation study of anti-hypoxia active fraction of Xiangdan injection.
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Pharmacodynamic screening and simulation study of anti-hypoxia active fraction of Xiangdan injection.

机译：香丹注射液抗缺氧活性成分的药效筛选和模拟研究。

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ETHNOPHARMACOLOGICAL RELEVANCE: The herbal formula Xiangdan injection and its modifications have been used in traditional Chinese medicine for about hundreds years to alleviate pain and promoting blood. AIM: To investigate the anti-hypoxia active fraction of Xiangdan injection. MATERIALS AND METHODS: Xiangdan injection was extracted by ligarine, chloroform, acetic ether, n-butanol and water, represented respectively by A, B, C, D and E. Five extractions were group on the L12(2(5)) orthogonal designed table. NIH mices anti-hypoxia experiment under normal pressure with rats was adopted on the basis of orthogonal design, prediction pharmacodynamics model of TCM prescriptions was established, and the simulation bias was evaluated by combining two scatterplots. The anti-hypoxia active fraction of Xiangdan injection was determined by experiments. RESULTS: The prediction model of TCM prescriptions established in this study can predict the drug actions for different formulas, and PE%
机译：族裔药理关系：香丹丹中草药制剂及其改良剂已在中药中使用了约数百年，以减轻疼痛和促进血液。目的：研究香丹注射液的抗缺氧活性成分。材料与方法：香丹注射液是用甜菜碱，氯仿，乙酸，正丁醇和水提取的，分别用A，B，C，D和E表示。在正交设计的L12（2（5））上进行了5次提取。表。在正交试验的基础上，采用NIH小鼠常压大鼠抗缺氧实验，建立了中药处方药效学预测模型，并结合两个散点图对模拟偏倚进行了评价。通过实验确定了香丹注射液的抗缺氧活性成分。结果：本研究建立的中药处方预测模型可以预测不同配方的药物作用，在112只小鼠（93.3％）中观察到PE％<或= 25％。结论：如模型预测和实验确认所示，这5种配方的药效作用均优于原始配方，而ADE的效果最好。

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