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首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >A traditional Chinese herbal preparation, Er-Zhi-Wan, prevent ovariectomy-induced osteoporosis in rats
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A traditional Chinese herbal preparation, Er-Zhi-Wan, prevent ovariectomy-induced osteoporosis in rats

机译：一种传统的中草药制剂“二枝万”可预防卵巢切除术诱发的大鼠骨质疏松

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Ethnopharmacological relevance: Er-Zhi-Wan (EZW), a classic Chinese formulation, which contains Fructus Ligustri Lucidi (FLL) and Herba Ecliptae (HE). EZW is widely used to prevent and treat various kidney diseases for its actions of nourishing the kidney and strengthening tendon and bone. Although recent reports indicate that EZW restrains osteoclastic bone resorption, its effects on the protection against define OVX-induced bone loss in mature rats have not been systematically investigated. Materials and methods: Sixty 3-month-old female Sprague-Dawley rats were randomly assigned into sham-operated group (Sham) and five OVX subgroups, OVX with vehicle (OVX); OVX with Estradiol Valerate (EV, 0.4 mg/kg body weight/day); OVX with EZW of graded doses (9.0, 4.5, or 2.25 g/kg/day). Daily oral administration of EV and EZW on 5th week for 26 weeks. Bone turnover markers (Serum alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BALP), osteocalcin (OCN), deoxypyridinoline (DPD)), other parameters, including serum calcium (S-Ca), serum phosphorus (S-P), urine calcium (U-Ca), phosphorus (U-P), and bone mineral density (BMD) of the femur, 4th lumbar vertebra and tibia, bone biomechanical properties and trabecular microarchitecture parameters were measured. Results: Administration of EZW could significantly prevent ovariectomy-induced bone loss, biomechanical reduction, deterioration of trabecular microarchitecture and the body weight gain without affecting the weight of the uterus, and increased S-Ca, S-P levels, decreased level of bone turnover markers and U-Ca, U-P levels in ovariectomized rats. Conclusion: The present study indicated that EZW had a definite antiosteoporotic effect without hyperplastic effect on uterus, and it might be a potential alternative medicine for treatment of postmenopausal osteoporosis.
机译：人种药理学相关性：一种经典的中药配方，即药芝Er（EZW），其中含有Li药（FLL）和and草（HE）。 EZW具有滋补肾脏，增强肌腱和骨骼的作用，被广泛用于预防和治疗各种肾脏疾病。尽管最近的报道表明EZW抑制破骨细胞的骨吸收，但尚未系统地研究其对保护OVX所致骨丢失的保护作用。材料和方法：60只3个月大的Sprague-Dawley雌性大鼠随机分为假手术组（Sham）和5个OVX亚组，OVX带载体（OVX）。 OVX与戊酸雌二醇（EV，0.4 mg / kg体重/天）; EZW的OVX分级剂量（9.0、4.5或2.25 g / kg /天）。第5周每天口服EV和EZW，共26周。骨转换指标（血清碱性磷酸酶（ALP），骨特异性碱性磷酸酶（BALP），骨钙素（OCN），脱氧吡啶啉（DPD）），其他参数，包括血清钙（S-Ca），血清磷（SP），尿液测量股骨，第4腰椎和胫骨的钙（U-Ca），磷（UP）和骨矿物质密度（BMD），骨的生物力学性能和小梁微结构参数。结果：EZW的使用可以显着预防卵巢切除术引起的骨丢失，生物力学降低，小梁微结构恶化和体重增加，而不会影响子宫重量，并且增加S-Ca，SP水平，降低骨代谢指标和降低骨代谢指标去卵巢大鼠的U-Ca，UP水平。结论：本研究表明EZW对子宫有一定的抗骨质疏松作用，而对子宫没有增生作用，它可能是治疗绝经后骨质疏松症的潜在替代药物。

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