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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >EEG Hemispheric Asymmetries During Cognitive Tasks in Depressed Patients With High Versus Low Trait Anxiety
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EEG Hemispheric Asymmetries During Cognitive Tasks in Depressed Patients With High Versus Low Trait Anxiety

机译：脑电图半球不对称认知任务期间抑郁患者高vs低特质焦虑

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Studies of regional hemispheric asymmetries point to relatively less activity in left frontal and right posterior regions in depression. Anxiety was associated with increased right posterior activity, which may be related to arousal and, in anxious-depressed individuals, offset the posterior asymmetry typically seen in depression. These asymmetries have been indexed by resting EEG or inferred through the use of lateralized auditory and visual tasks (e.g., dichotic listening and chimeric faces). However, associations between regional EEG activity and neurocognitive function in depression or anxiety remain unclear. The present study used matched verbal (Word Finding) and spatial (Dot Localization) tasks to compare task-related alpha asymmetries in depressed patients grouped according to level of trait anxiety. EEG and behavioral performance were recorded from depressed patients with high anxiety (n=14) or low anxiety (n=14) and 21 age- and education-matched healthy adults during the two tasks, and alpha power was averaged within each task. As predicted, the two patient groups exhibited opposite patterns of regional hemispheric alpha asymmetry. Greater right than left central-parietal activation was seen in the high-anxiety depressed group during the spatial task, whereas greater left than right frontal-central activation was found in the low-anxiety depressed group during the verbal task. Group differences in task performance were in the expected direction but did not reach statistical significance. These results are consistent with Heller's two-dimensional model of depression and anxiety and highlight the sensitivity of task-related EEG alpha in discriminating among subgroups of depressed patients differing in trait anxiety.
机译：对区域半球不对称性的研究表明，抑郁症左额叶和右后叶区域的活动相对较少。焦虑与右后方活动的增加有关，这可能与唤醒有关，在焦虑抑郁的个体中，可以抵消抑郁症中常见的后方不对称性。这些不对称现象可以通过静息的脑电图来索引，也可以通过使用侧向听觉和视觉任务（例如，双耳听觉和嵌合面孔）来推断。然而，在抑郁或焦虑中区域脑电活动与神经认知功能之间的关联仍不清楚。本研究使用匹配的口头（单词查找）和空间（点定位）任务来比较根据特质焦虑水平分组的抑郁症患者中与任务相关的α不对称性。在这两项任务中，记录了高焦虑（n = 14）或低焦虑（n = 14）的抑郁症患者和21名年龄和文化程度相匹配的健康成年人的脑电图和行为表现，并且平均每项任务的alpha功效。如预测的那样，两个患者组表现出相反的区域半球α不对称性模式。在空间任务中，高焦虑抑郁组的右顶中央激活比左侧更大，而在语言任务中低焦虑抑郁组的右前-中央中心激活比左侧大。小组在任务执行方面的差异在预期的方向上，但未达到统计学意义。这些结果与海勒的抑郁和焦虑的二维模型一致，并突出了任务相关的脑电图阿尔法在区分特质焦虑不同的抑郁患者亚组中的敏感性。

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