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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Aneurysmal Subarachnoid Hemorrhage in a Mexican Multicenter Registry of Cerebrovascular Disease: The RENAMEVASC Study
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Aneurysmal Subarachnoid Hemorrhage in a Mexican Multicenter Registry of Cerebrovascular Disease: The RENAMEVASC Study

机译：墨西哥脑血管疾病多中心注册中心的动脉瘤性蛛网膜下腔出血：RENAMEVASC研究

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摘要

Background: Information on risk factors and outcome of persons with aneurysmal subarachnoid hemorrhage (SAH) in Mexico is unknown. We sought to describe the clinical characteristics, risk factors, and outcome at discharge of Mexican patients with aneurysmal SAH. Methods: A first-step surveillance system was conducted on consecutive cases confirmed by 4-vessel angiography from November 2002 to October 2004 in 25 tertiary referral centers. Age- and sex-matched control subjects were randomly selected by a 1:1 factor, for multivariate analysis on risk factors. Results: We studied 231 patients (66% women; mean age 52 years, range 16-90 years). In 92%, the aneurysms were in the anterior circulation, and 15% had more than two aneurysms. After multivariate analysis, hypertension (odds ratio 2.46, 95% confidence interval 1.59-3.81) and diabetes mellitus (odds ratio 0.34,95% confidence interval 0.17-0.68) were directly and inversely associated with aneurysmal SAH, respectively. Median hospital stay was 23 days (range 2-98 days). Invasive treatment was performed in 159 (69%) patients: aneurysm clipping in 126 (79%), en-dovascular coiling in 29 (18%), and aneurysm wrapping in 4 (2%). The in-hospital mortality was 20% (mostly due to neurologic causes), and 25% of patients were discharged with a modified Rankin score of 4 or 5. Conclusions: Hypertension is the main risk factor for aneurysmal SAH in hospitalized patients from Mexico. The fe-male:male ratio is 2:1. A relatively low in-hospital mortality and a high frequency of invasive interventions are observed. However, a high proportion of patients are discharged with important neurologic impairment.
机译：背景：在墨西哥，有关动脉瘤性蛛网膜下腔出血（SAH）患者的危险因素和预后的信息尚不清楚。我们试图描述墨西哥特征性SAH动脉瘤患者的临床特征，危险因素和结局。方法：从2002年11月至2004年10月，在25个三级转诊中心对4支血管造影确诊的连续病例进行了第一步监测系统。按1：1的比例随机选择年龄和性别匹配的对照受试者，以对危险因素进行多变量分析。结果：我们研究了231例患者（66％的女性;平均年龄52岁，范围16-90岁）。在92％的患者中，动脉瘤位于前循环中，而15％的患者具有两个以上的动脉瘤。经过多因素分析后，高血压（比值比为2.46，95％置信区间为1.59-3.81）和糖尿病（比值比为0.34,95％置信区间为0.17-0.68）分别与动脉瘤SAH直接相关，并呈负相关。住院中位时间为23天（范围2-98天）。 159（69％）位患者进行了侵入性治疗：126例（79％）夹住动脉瘤，29例（18％）进行血管内盘绕，4例（2％）包裹动脉瘤。院内死亡率为20％（主要是由于神经系统原因），出院的25％患者的兰金评分修改为4或5。结论：高血压是墨西哥住院患者动脉瘤SAH的主要危险因素。男女之比为2：1。观察到院内死亡率相对较低，侵入性干预的频率较高。但是，有很大一部分患者出院时患有严重的神经系统损害。

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