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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Cognitive Consequences of Multiple Lacunes and Leukoaraiosis as Vascular Cognitive Impairment in Community-Dwelling Elderly Individuals
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Cognitive Consequences of Multiple Lacunes and Leukoaraiosis as Vascular Cognitive Impairment in Community-Dwelling Elderly Individuals

机译：社区居民老年人多发性腔隙性脑病和白细胞增多症的认知后果作为血管性认知障碍。

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The aim of our study was to investigate the effects of silent brain lesions on cognitive function of community-dwelling elderly individuals. Brain magnetic resonance imaging and other medical examinations were performed on 350 nondemented elderly individuals (121 male and 229 female, average age 72.4 years) who resided in the rural community of Sefuri Village, Saga, Japan. The mini mental state examination and modified Stroop test (MST) were used to identify cognitive impairment. White matter lesions (WMLs) and cerebral atrophy on magnetic resonance imaging were measured quantitatively. Multivariate analyses were done using a logistic regression model with a software package. Cognitive impairment defined by mini mental state examination score less than 24 was present in 55 individuals (15.7%). They had a lower educational level, significantly larger quantity of WMLs, and more remarkable cerebral atrophy. Frontal lobe dysfunction was detected in 52 individuals (14.9%) through prolonged MST score (>36 seconds). Impaired frontal lobe function was related to number of silent lacunar infarcts., larger WMLs, and more prominent cerebral atrophy. MST score in individuals with two or more infarcts was significantly more prolonged compared with MST score in those without infarction. These results suggest that WMLs may cause rather diffuse cognitive decline, whereas multiple lacunar infarcts are specifically involved in frontal lobe dysfunction. Silent is-chemic lesions in apparently healthy elderly individuals seem to form a distinctive group of people with vascular cognitive impairment without dementia. This group should be the primary target of prevention of vascular dementia.
机译：我们研究的目的是调查沉默的脑部病变对社区老年人的认知功能的影响。对居住在日本佐贺县Sefuri村农村地区的350名无痴呆的老年个体（121名男性和229名女性，平均年龄72.4岁）进行了脑磁共振成像和其他医学检查。迷你精神状态检查和改良的Stroop测验（MST）用于识别认知障碍。定量测量磁共振成像中的白质病变（WML）和脑萎缩。使用带有软件包的逻辑回归模型进行多变量分析。迷你精神状态检查分数定义的认知障碍在24人中，不足24（15.7％）。他们的文化程度较低，WML数量明显较多，脑萎缩更为明显。通过延长的MST评分（> 36秒）检测到52位个体（14.9％）的额叶功能障碍。额叶功能受损与无声腔隙性梗塞的数目，更大的WML和更明显的脑萎缩有关。与没有梗塞的患者相比，有两个或更多梗塞的患者的MST评分显着延长。这些结果表明，WMLs可能引起相当程度的认知功能减退，而多发腔隙性梗塞特别涉及额叶功能障碍。在显然健康的老年人中，沉默的缺血性病变似乎形成了一组独特的具有血管性认知功能障碍而无痴呆的人群。该组应该是预防血管性痴呆的主要目标。

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