...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >A simple electrocardiogram marker for risk stratification of ischemic stroke in low-resources settings.
【24h】

A simple electrocardiogram marker for risk stratification of ischemic stroke in low-resources settings.

机译：一种简单的心电图标记，可在资源贫乏地区对缺血性中风的危险分层。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Because of economic constraints, identification of patients at high risk for ischemic stroke who may benefit from further evaluation and aggressive control of their risk factors carries a special importance in low-resources settings. We sought to examine the use of the negative component of the P wave in V(1) in the standard electrocardiogram, referred to as P-wave terminal force (PTF), as a risk stratification tool of ischemic stroke in Africans living in Malawi, a sub-Saharan African country where stroke is a strongly emerging health problem. METHODS: This was a case-comparison study where 92 patients with ischemic stroke were compared with an equal number of subjects in an age- and sex-matched comparison group. The sensitivity and specificity of abnormal PTF, defined as PTF greater than or equal to 4mm-s, to diagnose ischemic stroke were calculated. Univariate and multivariable logistic regression analysis was used to estimate the odds of ischemic stroke associated with abnormal PTF. RESULTS: Abnormal PTF was present in 54% of patients with stroke compared with only 17% of the comparison group (P < .001). The specificity and sensitivity of PTF was 82% and 54%, with positive and negative predictive values of 76% and 64%, respectively. PTF was associated with ischemic stroke in a univariate analysis (odds ratio [OR] 5.7; 95% confidence interval [CI] 2.9-11.1), a multivariate analysis adjusting for common ischemic stroke risk factors (OR 2.8; 95% CI 2.4-3.4), and even with further adjustment for echocardiographically measured left atrial size (OR 2.1; 95% CI 1.9-2.4). CONCLUSIONS: PTF greater than or equal to 4mm-s is associated with the risk of ischemic stroke in Africans independently from ischemic stroke risk factors. Given its reasonable sensitivity and specificity to predict ischemic stroke, PTF greater than or equal to 4mm-s could be used as a risk stratification tool to discriminate between patients at high and low risk of ischemic stroke, and subsequently identify patients who may benefit from further evaluation and aggressive control of their risk factors.
机译：背景：由于经济上的限制，对缺血性中风高危患者的识别可能会受益于对其风险因素的进一步评估和积极控制，这在资源匮乏的环境中尤为重要。我们试图研究在标准心电图中V（1）中P波的负分量（称为P波终端力（PTF））在居住于马拉维的非洲人中作为缺血性卒中的危险分层工具的使用，撒哈拉以南非洲国家，中风是一个非常严重的健康问题。方法：这是一项病例比较研究，在年龄和性别匹配的比较组中，将92例缺血性中风患者与相同数目的受试者进行了比较。计算了异常PTF（定义为PTF大于或等于4mm-s）对缺血性中风的敏感性和特异性。使用单变量和多变量logistic回归分析来估计与异常PTF相关的缺血性卒中的几率。结果：54％的中风患者存在异常的PTF，而对照组的这一比例仅为17％（P <.001）。 PTF的特异性和敏感性分别为82％和54％，阳性和阴性预测值分别为76％和64％。在单因素分析中，PTF与缺血性卒中相关（比值比[OR] 5.7; 95％置信区间[CI] 2.9-11.1），该变量用于调整常见的缺血性卒中危险因素（OR 2.8; 95％CI 2.4-3.4） ），甚至可以进一步调整以超声心动图测量的左心房大小（OR 2.1; 95％CI 1.9-2.4）。结论：PTF大于或等于4mm-s与非洲人缺血性中风的风险相关，而与缺血性中风的危险因素无关。鉴于其对缺血性卒中的预测具有合理的敏感性和特异性，大于或等于4mm-s的PTF可以用作风险分层工具，以区分缺血性卒中高危和低危患者，并随后识别出可能从进一步受益中受益的患者评估和积极控制其危险因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号