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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >In vitro testing of a new aspiration thrombus device.
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In vitro testing of a new aspiration thrombus device.

机译：新型抽吸血栓装置的体外测试。

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BACKGROUND: Mechanical thrombectomy can restore blood flow to the brain after acute ischemic stroke, but may be associated with risks, such as breakage of moving parts and clot fragmentation. The aim of this study was to evaluate a new aspiration thrombus device (ATD), the GP ATD, which has no moving parts and extracts clots by suction in a vortex flow pattern. METHODS: The GP ATD is used to extract porcine blood clots inserted into the middle cerebral artery (MCA) of a model of the circle of Willis, and from porcine aorta. RESULTS: The GP ATD is navigable around the acute angles of the circle of Willis model and successfully extracts clots that cause complete occlusion of the MCA. There is a strong correlation between the pressure required for clot extraction (mean 31.8, range 30-34 kPa) and its mass (mean 0.08, range 0.03-0.13 g). Complete clot extraction can be demonstrated by computed tomography scanning. Lysis of a 0.15-g thrombus using alteplase at a concentration of 3.4 microg/mL was more effective when delivered and extracted via the GP ATD than via a catheter without the GP ATD or delivered systemically in our circle of Willis model and extracted without suction (clot mass after extraction 0.07, 0.09, and 0.11 g, respectively). Histologic examination does not show evidence of damage of the arterial wall caused by clot extraction at suction pressures of up to 30 kPa via the GP ATD. CONCLUSION: The GP ATD appears to effectively extract blood clots from models of the MCA without significant clot fragmentation and damage to the arterial wall. Further experiments using arteries in situ are required to confirm these findings.
机译：背景：机械性血栓切除术可在急性缺血性中风后恢复大脑的血流，但可能与诸如活动部件破裂和血凝块碎裂等风险相关。这项研究的目的是评估一种新的抽吸血栓装置（ATD）GP ATD，它没有运动部件，并且通过抽吸以涡流方式抽吸血块。方法：GP ATD用于从猪主动脉中提取插入到Willis环模型的大脑中动脉（MCA）中的猪血凝块。结果：GP ATD可以在Willis模型圆的锐角周围导航，并成功地提取出导致MCA完全闭塞的血块。凝块提取所需的压力（平均31.8，范围30-34 kPa）与其质量（平均0.08，范围0.03-0.13 g）之间具有很强的相关性。完全的血块提取可以通过计算机断层扫描来证明。通过阿替普酶以3.4微克/毫升的浓度溶解0.15克血栓时，通过GP ATD输送和提取比通过不使用GP ATD的导管或在我们的Willis模型圈中全身输送并无抽吸提取的方法更有效（提取后的凝块质量分别为0.07、0.09和0.11 g）。组织学检查未显示出通过GP ATD在高达30 kPa的吸入压力下提取血块引起的动脉壁受损的证据。结论：GP ATD似乎可以有效地从MCA模型中提取血凝块，而没有明显的血凝块碎裂和对动脉壁的损害。需要进一步使用原位动脉的实验来证实这些发现。

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