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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Cerebral venous sinus thrombosis presenting as transient ischemic attacks in a case with homozygous mutations of MTHFR A1298C and CG677T
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Cerebral venous sinus thrombosis presenting as transient ischemic attacks in a case with homozygous mutations of MTHFR A1298C and CG677T

机译：在MTHFR A1298C和CG677T纯合突变的情况下，脑静脉窦血栓形成为短暂性缺血发作

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We report a case with recurrent, transient attacks of slurred speech, weakness, and numbness of the right half of the face and the right arm without seizure activity, accompanied by headache and double vision. Neurologic examination revealed bilateral papilledema and right abducens palsy. Brain magnetic resonance imaging revealed thrombosis of the dural venous sinuses and the cortical veins, with no evidence of parenchymal lesion. Homozygous mutations were found for methylenetetrahydrofolate reductase (MTHFR) A1298C and MTHFR CG677T. Anticoagulation with heparin and warfarin resulted in prompt cessation of the transient attacks, as well as the signs and symptoms of increased intracranial pressure. This report documents that, although rare, transient ischemic attacks can result from cerebral venous thrombosis.
机译：我们报道一例复发性，短暂性发作，口齿不清，无力和右半脸和右臂麻木，无癫痫发作，伴有头痛和复视。神经系统检查显示双侧乳头水肿和右外展神经麻痹。脑磁共振成像显示硬脑膜静脉窦和皮层静脉血栓形成，没有实质性病变的迹象。发现亚甲基四氢叶酸还原酶（MTHFR）A1298C和MTHFR CG677T的纯合突变。肝素和华法林的抗凝治疗可迅速终止短暂性发作，以及颅内压升高的体征和症状。该报告证明，尽管罕见，但短暂性缺血发作可能是由脑静脉血栓形成引起的。

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