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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Ischemic lesion burden and characteristics of aortic atheroma
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Ischemic lesion burden and characteristics of aortic atheroma

机译：缺血性病变负荷和主动脉粥样硬化的特征

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Background: To investigate whether ischemic lesion burden including lesion pattern, number, and volume would vary depending on risk stratification of aortic atheroma (AA). Methods: Acute stroke patients were enrolled if they had (1) acute ischemic lesions on diffusion-weighted imaging within 5 days of symptom onset, (2) cardioembolic stroke established through extensive workup, and (3) only ascending or arch AA detected by transesophageal echocardiography as an embolic source. AA was classified as complex (protruding ≥4 mm into the aortic lumen or any mobile or ulcerative component) or simple (<4 mm). Results: Eighty-one patients (male: 65.4% and age: 66.7 ± 11.0 years) were included in the study. Thirty-four patients (41.9%) had complex atheroma. These patients had a greater number of ischemic lesions (median: 2 lesions [range: 1-42] versus one lesion [range: 1-27], P =.017) and a larger infarct size (9.01 cc [range: 3.58-49.14] versus 4.6 cc [range: 2.3-13.28), P =.056) than the simple atheroma group. Multivariable logistic regression analysis showed that ischemic lesion volume was independently associated with complex atheroma (odds ratio: 1.03, 95% confidence interval: 1.002-2.148, P =.035), while multiple lesions were related (odds ratio: 3.03, 95% confidence interval:.88-10.42, P =.079). Conclusions: Ischemic lesion burden in patients with AA differed according to AA characteristics, suggesting that the morphological features of AA could reflect an embolic potential of AA.
机译：背景：调查缺血性病变负担（包括病变类型，数量和体积）是否会根据主动脉粥样硬化（AA）的危险分层而有所不同。方法：招募急性卒中患者，如果他们（1）在症状发作后5天内进行弥散加权成像的急性缺血性病变，（2）通过广泛检查建立的心脏栓塞性卒中，以及（3）经食管仅检测到升支或弓形AA超声心动图作为栓塞源。 AA分为复杂型（伸入主动脉腔或任何活动或溃疡性成分≥4 mm）或简单型（<4 mm）。结果：本研究纳入了81位患者（男性：65.4％，年龄：66.7±11.0岁）。三十四名患者（41.9％）患有复杂的动脉粥样硬化。这些患者的缺血性病变数量较多（中位数：2个病变[范围：1-42]与一个病变[范围：1-27]，P = .017），梗死面积较大（9.01 cc [范围：3.58- 49.14]与4.6 cc [范围：2.3-13.28），P = .056）比单纯动脉粥样硬化组相比。多变量logistic回归分析显示，缺血性病变体积与复杂性动脉粥样硬化独立相关（几率：1.03，95％置信区间：1.002-2.148，P = .035），而多个病变相关（几率：3.03，95％置信度）区间：.88-10.42，P = .079）。结论：AA患者的缺血性病变负担因AA特征而异，提示AA的形态学特征可反映AA的栓塞潜力。

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