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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Is There an Association between Cerebral Microbleeds and Leukoaraiosis?
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Is There an Association between Cerebral Microbleeds and Leukoaraiosis?

机译：脑微出血与白细胞增多症之间有联系吗？

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Purpose: Cerebral microbleeds (CMBs) are small dot-like lesions appearing as hyposignals on gradient echo (GRE) T2* magnetic resonance (MR) sequences, whereas the leukoaraiosis (LA) indicates the presence of patchy areas of hypersignal on fluid-attenuated inversion recovery (FLAIR) MR sequences in the periventricular white matter. The purpose of this work was to evaluate the association between LA and CMBs. Material and Methods: Eighty-five consecutive (men 55; median age 64 years) patients were retrospectively analyzed using a 1.5 Tsystem; CMBs were studied using a T2*-weighted GRE sequence and classified as absent (grade 1), mild (grade 2; total number of microbleeds, 1-2), moderate (grade 3; total number of microbleeds, 3-10), and severe (grade 4; total number of microbleeds, >10). LA was assessed with FLAIR MR sequences and was graded based on the European Task Force on Age-Related White Matter Changes as follows: 1 (no lesions), 2 (focal lesions >5 mm), 3 (early confluent lesions), and 4 (diffuse involvement of an entire brain region). Results: We considered 170 cerebral hemispheres. The prevalence of CMBs was 24.7% (42 of 170), whereas the prevalence of LA was 27.1% (46 of 170). A statistically significant correlation was observed between LA and CMBs (correlation rho = .495, P value = .001). Multiple logistic regression analysis showed an association between CMBs and cerebrovascular symptoms (P = .0023). Conclusion: Results of this study suggest an association between CMBs and LA. Moreover, we found that LA is associated with the presence of cerebrovascular symptoms. (C) 2015 by National Stroke Association
机译：目的：脑微出血（CMB）是小的点状病变，在梯度回波（GRE）T2 *磁共振（MR）序列上显示为低信号，而白细胞疏松（LA）则表明在液体衰减倒置中存在高信号的斑片区域脑室周围白质中的恢复（FLAIR）MR序列。这项工作的目的是评估LA和CMB之间的关联。材料和方法：使用1.5 T系统回顾性分析了八十五名连续患者（男性55岁;中位年龄64岁）。使用T2 *加权GRE序列对CMB进行了研究，分类为不存在（1级），轻度（2级;微出血总数为1-2），中度（3级;微出血总数为3-10），和严重（4级;微出血总数，> 10）。用FLAIR MR序列评估LA，并根据欧洲与年龄有关的白色物质变化特别工作组进行了如下分级：1（无病变），2（局灶性病变> 5 mm），3（早期融合病变）和4 （扩散整个大脑区域）。结果：我们考虑了170个大脑半球。 CMB的患病率为24.7％（170个中的42个），而LA的患病率为27.1％（170个中的46个）。在LA和CMB之间观察到统计学上的显着相关性（相关rho = .495，P值= .001）。多元逻辑回归分析显示，CMB与脑血管症状之间存在关联（P = .0023）。结论：本研究结果表明CMB与LA之间存在关联。此外，我们发现LA与脑血管症状的存在有关。 （C）国家卒中协会2015年

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