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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Local O-2 Balance in Cerebral Ischemia-Reperfusion Improved during Pentobarbital Compared with Isoflurane Anesthesia
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Local O-2 Balance in Cerebral Ischemia-Reperfusion Improved during Pentobarbital Compared with Isoflurane Anesthesia

机译：与异氟烷麻醉相比，戊巴比妥期间脑缺血-再灌注的局部O-2平衡得到改善

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Background: Most anesthetics affect cerebral blood flow and metabolism. We compared microregional O-2 balance in cerebral ischemia-reperfusion during pentobarbital and isoflurane anesthesia. Methods: After 1 hour of middle cerebral artery occlusion and a 2-hour reperfusion under isoflurane (1.4%, n = 14) or pentobarbital (50 mg/kg, n = 14) anesthesia in rats, regional cerebral blood flow using C-14-iodoantipyrine autoradiography, microregional arterial and venous O-2 saturation (20-60 mu m in diameter) using cryomicrospectrophotometry, and the size of cortical infarct were determined. Results: Ischemia-reperfusion decreased the average cortical venous O-2 saturation in both pentobarbital and isoflurane groups (P < .0001), which was higher (P < .05) with pentobarbital despite a similar average regional cerebral blood flow and O-2 consumption. The heterogeneity of venous O-2 saturation reported as a coefficient of variation (100 x standard deviation/ mean) was smaller (P < .005) with pentobarbital than that with isoflurane (7.5 versus 16.1). The number of veins with low venous O-2 saturation (<50%) was smaller (P < .005) with pentobarbital (5 of 80 versus 24 of 80). The percentage of cortical infarct in total cortex was smaller with pentobarbital (5.2 +/- 2.5% versus 12.3 +/- 2.6%, P < .001). Conclusions: In the cerebral ischemic-reperfused cortex, the average venous O-2 saturation was higher, and its heterogeneity and the number of veins with low O-2 saturation were smaller under pentobarbital than isoflurane anesthesia. This improvement in microregional O-2 balance with pentobarbital was accompanied by the reduced cortical infarct. Our data suggest that the neurologic outcome could vary during cerebral ischemia-reperfusion depending on the anesthetics used.
机译：背景：大多数麻醉剂会影响脑部血液流动和新陈代谢。我们比较了戊巴比妥和异氟烷麻醉期间脑缺血-再灌注中微区O-2的平衡。方法：在异氟烷（1.4％，n = 14）或戊巴比妥（50 mg / kg，n = 14）麻醉下大鼠大脑中动脉闭塞1小时和2小时再灌注后，使用C-14进行局部脑血流-碘安替比林放射自显影，使用冷冻显微分光光度法测定微区动脉和静脉的O-2饱和度（直径20-60μm），并测定皮层梗塞的大小。结果：缺血再灌注降低了戊巴比妥组和异氟烷组的平均皮质静脉血氧饱和度（P <.0001）（P <.0001），尽管局部区域平均脑血流量和O-2相似，戊巴比妥组的平均皮质静脉血氧饱和度更高（P <.05）消费。以变​​异系数（100 x标准偏差/平均值）报告的静脉O-2饱和度的异质性，与异氟烷相比，戊巴比妥组较小（P <.005）（7.5对16.1）。戊巴比妥组的静脉O-2饱和度低（<50％）的静脉数量较少（P <.005）（80个中的5个对80个中的24个）。戊巴比妥组的总皮层梗死百分比较小（5.2 +/- 2.5％对12.3 +/- 2.6％，P <.001）。结论：与异氟烷麻醉相比，戊巴比妥在脑缺血再灌注皮层中的平均静脉O-2饱和度较高，其异质性和低O-2饱和度的静脉数目较小。戊巴比妥可改善微区O-2平衡，同时减少皮质梗塞。我们的数据表明，根据所使用的麻醉剂，在脑缺血再灌注过程中神经系统的预后可能会有所不同。

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