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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Older Women Benefit from Thrombolysis as Much as Older Men
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Older Women Benefit from Thrombolysis as Much as Older Men

机译：老年妇女与男性一样多地从溶栓治疗中受益

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Background: Although the incidence of stroke among older people increases, the use of intravenous thrombolysis has initially been restricted in the elderly. However, more people aged more than 80 years, a majority of them women, may benefit from thrombolysis. Therefore characteristics, outcome, and complications in older women (aged more than 80 years) undergoing thrombolysis are studied and compared to older men and to younger women (aged less than 80 years) to detect any gender and age differences. Methods: Retrospective study of stroke patients treated with thrombolysis based on data collected from medical records. Outcome and complications were analyzed in 3 groups in relation to age and gender. Results: From a total of 108 patients treated with thrombolysis, 94 could be included in the study (36 women >= 80 years, 23 men >= 80 years, and 35 women <80 years). Improvement over the first 24 hours and at 3 months, and mortality were comparable between older women and men. Older women had more major strokes, a higher mortality, and 3-month morbidity than younger women. There was no significant difference in intracranial hemorrhage between the groups. Conclusions: We found no significant difference between older women and men in outcome and mortality after thrombolysis. Older women suffered from more severe strokes, and had a higher mortality and worse outcome than younger women. The frequency of intracranial hemorrhage was comparable. Given the higher percentage of older women suffering from more severe strokes, our results emphasize that thrombolysis should not be withheld exclusively based on age.
机译：背景：尽管老年人中风的发生率增加，但最初限制老年人使用静脉溶栓治疗。但是，更多的80岁以上的人（其中大多数是女性）可能会受益于溶栓治疗。因此，研究了溶栓的老年妇女（80岁以上）的特征，结局和并发症，并将其与老年男性和年轻妇女（80岁以下）进行比较，以发现性别和年龄差异。方法：根据从病历中收集的数据，对接受溶栓治疗的中风患者进行回顾性研究。根据年龄和性别对3组的结果和并发症进行了分析。结果：在总共108例接受溶栓治疗的患者中，有94例被纳入研究（36位> = 80岁的女性，23位> = 80岁的男性和35位<80岁的女性）。老年妇女和男子在头24小时和3个月内的改善情况和死亡率相当。老年妇女比年轻妇女有更大的中风，更高的死亡率和3个月的发病率。两组之间的颅内出血无明显差异。结论：我们发现老年男女在溶栓后的预后和死亡率方面无显着差异。年长的妇女比中年妇女遭受更严重的中风，死亡率更高，预后更差。颅内出血的频率是可比的。鉴于中风发作较严重的老年妇女比例较高，我们的研究结果强调不应仅根据年龄停止溶栓。

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