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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Increased Cortical Cerebral Blood Flow in Asymptomatic Human Immunodeficiency Virus-Infected Subjects
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Increased Cortical Cerebral Blood Flow in Asymptomatic Human Immunodeficiency Virus-Infected Subjects

机译：在无症状的人类免疫缺陷病毒感染的受试者中皮质脑血流量增加。

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Background: Human immunodeficiency virus (HIV)-infected individuals are at high risk for ischemic stroke. To investigate the physiological basis for this risk, we used magnetic resonance imaging (MRI) to measure oxygen extraction fraction (OEF) and cerebral blood flow (CBF) in treatment-naive asymptomatic HIV-infected subjects and controls. Methods: In treatment-naive asymptomatic HIV-infected subjects and age-, gender-, and race-matched controls, OEF was measured by MRI asymmetric spin-echo echo-planar imaging sequences and CBF was measured by MRI pseudocontinuous arterial spin labeling. Results: Twenty-six treatment-naive HIV-infected subjects and 27 age-, gender-, race-matched controls participated. Whole-brain, gray matter (GM), and white matter OEF were not different between the groups (all P > .70). Unexpectedly, HIV-infected subjects had significantly higher CBF in cortical GM (72.9 +/- 16.2 mL/100g/min versus 63.9 +/- 9.9 mL/100g/min; P = .01) but not in subcortical GM (P = .25). Conclusions: The observed increase in cortical GM CBF in treatment-naive HIV-infected subjects is unexpected, contrary to CBF decreases reported in HIV-infected subjects on treatment, and may represent an initial increase in metabolic activity due to an HIV-mediated inflammation.
机译：背景：感染人类免疫缺陷病毒（HIV）的个体患缺血性中风的风险很高。为了调查这种风险的生理基础，我们使用了磁共振成像（MRI）来测量未经治疗的无症状HIV感染者和对照组中的氧气提取率（OEF）和脑血流量（CBF）。方法：在未接受过治疗的无症状HIV感染者以及年龄，性别和种族匹配的对照中，通过MRI非对称自旋回波平面成像序列测量OEF，通过MRI伪连续动脉自旋标记法测量CBF。结果：26名未接受过治疗的未感染HIV的受试者和27位年龄，性别，种族匹配的对照组参加了研究。两组之间的全脑，灰质（GM）和白质OEF无差异（所有P> .70）。出乎意料的是，感染HIV的受试者皮层GM的CBF显着更高（72.9 +/- 16.2 mL / 100g / min，而63.9 +/- 9.9 mL / 100g / min; P = 0.01），而皮层下GM则没有（C =。 25）。结论：在未接受过治疗的HIV感染者中观察到的皮质GM CBF的增加是出乎意料的，这与治疗后在HIV感染者中报告的CBF降低相反，并且可能代表了由HIV介导的炎症引起的代谢活性的最初增加。

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