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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Clinical features of a first-ever lacunar infarction in Japanese patients: poor outcome in females.
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Clinical features of a first-ever lacunar infarction in Japanese patients: poor outcome in females.

机译：日本患者首次出现腔隙性脑梗死的临床特征：女性预后不良。

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Lacunar infarction (LI) remains an important stroke subtype in Japan. The aim of this study was to investigate the characteristics of outcome determinants in LI. This study was a single center observational study and included 163 consecutive patients (108 male, 55 female; mean age 69 years). The National Institutes of Health Stroke Scale (NIHSS) score on admission and the modified Rankin scale (mRS) score at discharge were used to evaluate stroke severity. We determined the location of the infarct, the grade of white matter hyperintensity (WMH), and the prevalence of silent brain infarcts, hypertension, hypercholesterolemia, diabetes mellitus, ischemic heart disease, and smoking. We compared 2 groups, good outcome (mRS score 0-2) and poor outcome (mRS score 3-5), using multiple logistic regression analysis. We found significant differences between the 2 groups according to female sex (P = .04), WMH (P = .04), and NIHSS score (P < .001). After multivariate analysis, female sex (odds ratio [OR] = 3.4, 95% confidence interval [CI] = 1.1-11.4; P = .03), and NIHSS score (OR = 2.3, 95% CI = 1.7-3.3; P < .001) were independently associated with poor outcome. Elderly onset, poor outcome, and hypercholesterolemia were more common in female patients, whereas smoking was more prevalent in males. Our data indicate that sex differences exist in Japanese LI patients with regard to risk factors and outcome. The treatment of risk factors based on sex differences is important to the management of LI.
机译：在日本，腔隙性梗塞（LI）仍然是重要的中风亚型。这项研究的目的是调查LI的决定因素的特征。该研究是一项单中心观察性研究，纳入了163名连续患者（男108例，女55例;平均年龄69岁）。美国国立卫生研究院卒中量表（NIHSS）评分和出院时改良的兰金量表（mRS）评分用于评估卒中严重程度。我们确定了梗死的位置，白质高血压（WMH）的等级以及无症状性脑梗死，高血压，高胆固醇血症，糖尿病，缺血性心脏病和吸烟的患病率。我们使用多元逻辑回归分析比较了两组，即好结果（mRS评分0-2）和差的结果（mRS评分3-5）。我们发现两组根据女性性别（P = .04），WMH（P = .04）和NIHSS评分（P <.001）有显着差异。经过多变量分析后，女性（比值比[OR] = 3.4，95％置信区间[CI] = 1.1-11.4; P = .03）和NIHSS评分（OR = 2.3，95％CI = 1.7-3.3; P <.001）与不良预后独立相关。女性患者中老年人发病，不良结局和高胆固醇血症更为常见，而男性患者中吸烟更为普遍。我们的数据表明，日本LI患者在危险因素和预后方面存在性别差异。基于性别差异的危险因素的治疗对LI的管理很重要。

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