...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Correlation between severity of carotid stenosis and vascular reserve measured by acetazolamide brain perfusion single photon emission computed tomography
【24h】

Correlation between severity of carotid stenosis and vascular reserve measured by acetazolamide brain perfusion single photon emission computed tomography

机译：乙酰唑胺脑灌注单光子发射计算机断层扫描测量颈动脉狭窄严重程度与血管储备之间的相关性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Few studies have investigated the relationship between the degree of stenosis of the internal carotid artery (ICA) and cerebrovascular reserve (CVR). This study examined that relationship. A total of 56 ICAs in 43 patients were included. Computed tomography scan or magnetic resonance imaging showed no evidence of infarction in any of these patients. Both iodine-123-N-isopropyl-p- iodoamphetamine (123IMP)-single photon emission computed tomography (SPECT) in the resting state and 123IMP-SPECT with acetazolamide (ACZ) enhancement were performed. Quantitated cerebral blood flow (CBF) images were acquired with the 123IMP autoradiography technique. The mean CBF without ACZ administration (resting CBF) and CVR in the middle cerebral artery territory were calculated using stereotactic extraction estimation (SEE) analysis software. The degree of stenosis in the origin of the ICA was calculated from intra-arterial digital subtraction angiography. Resting CBF was not correlated with the degree of ICA stenosis; however, nonlinear regression analysis (second-order equation) showed a moderate correlation between CVR and the degree of ICA stenosis. In 72% of the cases with a CVR 30%, ICA stenosis was 74%. Using the SEE method, CVR was moderately correlated with the degree of ICA stenosis. Our findings indicate that evaluating CVR by ACZ-enhanced 123IMP-SPECT in patients with ICA stenosis is of clinical value.
机译：很少有研究调查颈内动脉狭窄程度（ICA）与脑血管储备（CVR）之间的关系。这项研究检查了这种关系。总共纳入了43例患者中的56个ICA。在所有这些患者中，计算机断层扫描或磁共振成像均未显示梗塞迹象。进行了静息状态下的碘-123-N-异丙基-对-碘苯丙胺（123IMP）-单光子发射计算机断层扫描（SPECT）和乙酰乙酰唑胺（ACZ）增强的123IMP-SPECT。使用123IMP放射自显影技术获取定量的脑血流（CBF）图像。使用立体定向提取估计（SEE）分析软件计算未使用ACZ的平均CBF（静息CBF）和大脑中动脉区域的CVR。根据动脉内数字减影血管造影术计算ICA起源的狭窄程度。静息CBF与ICA狭窄程度无关。但是，非线性回归分析（二阶方程）显示CVR与ICA狭窄程度之间存在中等相关性。在CVR小于30％的病例中，有72％的ICA狭窄大于74％。使用SEE方法，CVR与ICA狭窄程度呈中等相关性。我们的研究结果表明，通过ACZ增强的123IMP-SPECT评估ICA狭窄患者的CVR具有临床价值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号