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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >High blood pressure on admission in relation to poor outcome in acute ischemic stroke with intracranial atherosclerotic stenosis or occlusion
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High blood pressure on admission in relation to poor outcome in acute ischemic stroke with intracranial atherosclerotic stenosis or occlusion

机译：与颅内动脉粥样硬化狭窄或闭塞的急性缺血性卒中预后不良有关的入院时高血压

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Background Intracranial atherosclerotic stenosis is common in Asian, black, and Hispanic individuals. However, the management of blood pressure (BP) in the setting of acute stage in these patients is controversial. The present study aims to explore the relationship between BP on admission and outcomes in acute ischemic stroke patients with intracranial atherosclerotic stenosis or occlusion. Methods We prospectively registered consecutive cases of acute ischemic stroke from September 01, 2009, to August 31, 2011. Patients with severe intracranial stenosis or occlusion were included. Death or disability was followed up at the end of the third month. The multivariate logistic regression model was used to analyze the relationship between BP on admission and clinical outcomes. Results We included 215 cases, which accounted for 22.7% (215 of 946) of the total registered cases. The mean age was 60.44 ± 13.23 years. The median time of symptoms onset to admission was 72 hours (2-270 hours). Patients with systolic blood pressure (SBP) of 120-159 mm Hg or diastolic BP of 70-89 mm Hg had the lowest death or disability. After adjustment of confounders, SBP of 160 mm Hg or more on admission was the independent predictor of death or disability at the third month (relative risk [RR], 2.89; 95% confidence interval [CI], 1.20-6.91). SBP less than 120 mm Hg on admission had a trend of increasing death or disability (RR, 1.96; 95% CI,.60-6.33). Conclusions Higher BP on admission was associated with an increased risk of death or disability in patients with symptomatic intracranial artery stenosis or occlusion. It is reasonable that further studies on the effects of BP lowering in acute stroke include these patients.
机译：背景颅内动脉粥样硬化狭窄在亚洲人，黑人和西班牙裔患者中很常见。然而，这些患者在急性期的血压控制是有争议的。本研究旨在探讨急性缺血性卒中伴颅内动脉粥样硬化狭窄或闭塞的患者入院血压与预后之间的关系。方法我们从2009年9月1日至2011年8月31日连续登记急性缺血性中风病例，包括严重颅内狭窄或闭塞的患者。在第三个月末对死亡或残疾进行随访。多元逻辑回归模型用于分析入院时血压与临床结局之间的关系。结果共纳入215例，占登记病例总数的22.7％（946例）。平均年龄为60.44±13.23岁。症状发作至入院的中位时间为72小时（2-270小时）。收缩压（SBP）为120-159 mm Hg或舒张压为70-89 mm Hg的患者死亡或残疾最低。调整混杂因素后，入院时SBP为160 mm Hg或更高是第三个月死亡或残疾的独立预测因子（相对风险[RR]为2.89; 95％置信区间[CI]为1.20-6.91）。入院时SBP小于120 mm Hg有死亡或残疾增加的趋势（RR，1.96; 95％CI，.60-6.33）。结论症状性颅内动脉狭窄或闭塞患者入院时血压升高与死亡或致残风险增加有关。合理的是，对这些降低血压的急性卒中的进一步研究包括这些患者。

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