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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Statin use and risk of cerebral aneurysm rupture: A hospital-based case-control study in Japan
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Statin use and risk of cerebral aneurysm rupture: A hospital-based case-control study in Japan

机译：他汀类药物的使用和脑动脉瘤破裂的风险：日本一项基于医院的病例对照研究

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Background: Recent reports have showed that some statins have protective effects in experimental cerebral aneurysm models. We conducted a case-control study to investigate an association between statin use and the rupture risk of cerebral aneurysm in Japanese population. Methods: This was a multihospital case-control study; cases and controls were collected from 15 hospitals in Japan. Cases consisted of patients with aneurysmal subarachnoid hemorrhage hospitalized from April 2009 to March 2011. Controls were selected from patients who had newly diagnosed unruptured saccular aneurysms from April 2006 to March 2011. The primary exposure of interest was statin use. Multivariable logistic regression was used to assess the relationship between stain use and the rupture risk of cerebral aneurysm. Results: A total of 117 cases and 304 controls were included in the analyses. Statin was used in 9.4% of cases and 26.0% of controls. Controls had a significantly higher rate of use of statin. The use of any statin was associated with cerebral aneurysm rupture after adjustment of potential confounders (adjusted odds ratio:.30, 95% confidence interval:.14-.66). The association was similar in each stratum of total cholesterol level. Conclusions: This observation from a hospital-based case-control study in Japan suggested that there is inverse relationship between use of statins and cerebral aneurysm rupture. Future clinical studies are needed.
机译：背景：最近的报道表明，某些他汀类药物在实验性脑动脉瘤模型中具有保护作用。我们进行了一项病例对照研究，以研究他汀类药物的使用与日本人群脑动脉瘤破裂风险之间的关系。方法：这是一项多院病例对照研究。病例和对照是从日本15家医院收集的。病例包括从2009年4月至2011年3月住院的动脉瘤性蛛网膜下腔出血患者。对照组选自2006年4月至2011年3月新诊断为囊状动脉瘤未破裂的患者。主要关注对象是他汀类药物的使用。多变量logistic回归用于评估染色剂使用与脑动脉瘤破裂风险之间的关系。结果：总共包括117例病例和304例对照。在9.4％的病例和26.0％的对照中使用了他汀。对照组的他汀类药物使用率明显更高。调整潜在混杂因素后，使用任何他汀类药物都会导致脑动脉瘤破裂（调整后的优势比：.30，95％置信区间：.14-.66）。总胆固醇水平的各个层次之间的相关性相似。结论：来自日本一项基于医院的病例对照研究的观察结果表明，他汀类药物的使用与脑动脉瘤破裂之间存在反比关系。需要将来的临床研究。

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