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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Effect of Edaravone on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage
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Effect of Edaravone on Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage

机译：依达拉奉对实验性蛛网膜下腔出血后脑血管痉挛的影响

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摘要

The effect of the free radical scavenger edaravone on experimental cerebral vasospasm following subarachnoid hemorrhage (SAH) was investigated in a canine double hemorrhage model, Changes in the diameter of the basilar artery were assessed by serial angiography. The diameter ratio at day 7 was calculated as the percent of the basilar artery diameter of a given angiogram with respect to that of its control (day 0). The diameter ratios for the basilar artery following SAH in the control and vehicle-treated groups were 49.7% (+-) 3.9% (mean (+-) SEM) and 50,1% (+-) 1.7%, respectively. Edaravone was administered either by continuous intravenous injection for 7 days or by bolus injection for 7 days. Continuous administration of edaravone (1 mg/kg/hr or 10 mg/kg/hr) significantly attenuated the narrowing of the basilar artery following SAH. The diameter ratios in these groups were 71.3% (+-) 3.6% (1 mg/kg/hr) and 75,7% (+-) 1.7% (10 mg/kg/hr). Bolus administration of edaravone (3 mg/kg, every 12 hours) reduced the arterial narrowing following SAH. The diameter ratio on day 7 was 60.1% (+-) 3.3%, but the difference was not significant. These findings suggest that edaravone is effective in preventing cerebral vasospasm following SAH.
机译：在犬双重出血模型中研究了自由基清除剂依达拉奉对蛛网膜下腔出血（SAH）后实验性脑血管痉挛的影响，并通过连续血管造影评估了基底动脉直径的变化。将第7天的直径比计算为给定血管造影相对于其对照（第0天）的基底动脉直径的百分比。对照组和媒介物治疗组中SAH后基底动脉的直径比分别为49.7％（±）3.9％（平均（±）SEM）和50,1％（±）1.7％。依达拉奉通过连续静脉注射7天或推注7天来给药。连续施用依达拉奉（1 mg / kg / hr或10 mg / kg / hr）可显着减轻SAH后基底动脉的变窄。这些组的直径比分别为71.3％（±）3.6％（1 mg / kg / hr）和75.7％（±）1.7％（10 mg / kg / hr）。每次注射依达拉奉（3 mg / kg，每12小时一次）可以减轻SAH后的动脉狭窄。第7天的直径比为60.1％（±）3.3％，但差异不显着。这些发现表明依达拉奉可有效预防SAH后的脑血管痉挛。

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