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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Progressive Cognitive Impairment After Stroke
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Progressive Cognitive Impairment After Stroke

机译：中风后进行性认知障碍

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Objective: We examined the putative relationship between stroke and cognitive function in the population-based prospective cohort of the Cardiovascular Health Study (CHS). Methods: Of the 5888 participants of the CHS aged 65 years or older, there were 5364 with more than one modified mini-mental (3MS) examination between 1992 and 1998. To determine the effect of baseline stroke before first and subsequent (stroke between two consecutive examinations) 3MS examination on cognitive function, linear regression models were computed with potential confounders entered as additional independent variables, Stroke was divided into right and left hemispheres or posterior circulation on the basis of the clinical and/or imaging information by the hospital that treated the event and subsequent adjudication by CHS committee. Results: Participants with baseline stroke had an average 3MS decline of 1.2 (95% confidence interval [CI]: -0.7-1.7) points per year more than those without one. Those with a history of subsequent stroke had an average first year 3MS decline of 6.2 (CI-8.7-3.7) for left hemisphere, 3.5 (CI -5.3-1.8) for right hemisphere, and 1.1 (CI -3.9-1.6) for posterior circulation more than those without stroke. The effect of stroke on the rate of cognitive decline appeared to ameliorate after the first year (test for linear trend among those with stroke, P = .003). Conclusion: Results from this prospective population-based data study show that stroke in the left hemisphere results in a more pronounced decline in cognition than that in the right hemisphere and that cognitive loss because of stroke appears to attenuate over time, perhaps as a result of relearning.
机译：目的：我们在心血管健康研究（CHS）的人群前瞻性队列中研究了卒中与认知功能之间的推定关系。方法：在1992年至1998年之间，对5888名65岁或65岁以上的CHS参与者中的5364名进行了一项以上的改良式迷你智力测验（3MS）。连续检查）3MS认知功能检查，使用潜在的混杂因素作为附加自变量，计算线性回归模型，中风的医院根据临床和/或影像学信息将中风分为左右半球或后循环该事件以及CHS委员会的后续裁决。结果：基线卒中的参与者每年的3MS平均下降幅度比没有抑郁的参与者高1.2个百分点（95％置信区间[CI]：-0.7-1.7）。有继发性卒中史的患者第一年平均3MS下降率左半球为6.2（CI-8.7-3.7），右半球为3.5（CI -5.3-1.8），后半部为1.1（CI -3.9-1.6）血液循环比没有中风者更多。第一年后，中风对认知能力下降速度的影响似乎有所改善（对中风患者进行线性趋势检验，P = .003）。结论：这项基于人群的前瞻性数据研究的结果表明，左半球的中风导致的认知能力下降比右半球的更为明显，并且由于中风而导致的认知丧失似乎随着时间的流逝而减弱。再学习。

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