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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Cognitive Function After Carotid Endarterectomy:Greater Risk of Decline in Symptomatic Patients With Left Internal Carotid Artery Disease
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Cognitive Function After Carotid Endarterectomy:Greater Risk of Decline in Symptomatic Patients With Left Internal Carotid Artery Disease

机译：颈动脉内膜切除术后的认知功能：有症状的左颈内动脉疾病患者下降的风险更大

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Background: The risk of cognitive decline in patients undergoing carotid endarterectomy (CE) for left internal carotid artery (ICA) (LICA) disease before or after the occurrence of ischemic symptoms has not been fully elucidated. We evaluated whether patients undergoing CE for symptomatic LICA stenosis have greater risk of cognitive decline than patients with asymptomatic LICA disease or right ICA disease. Methods: In a series of patients aged 65 years and older, consecutively undergoing CE and free from cognitive impairment, cognitive function was evaluated through the age- and education-adjusted Mini Mental State Examination and the Clock Drawing Task at baseline and at the end of the study period (average follow-up: 44.4 ± 14.3 months)., Results: The analysis included 103 patients (mean age 72.6 ± 7.0 years; 73 men), of whom 50 had LICA disease (29 symptomatic). At the end of the study period, Mini Mental State Examination score was reduced in patients with symptomatic LICA disease (P < .001) but not in other patients, whereas the Clock Drawing Task score was reduced in both patients with LICA and right ICA. Patients with symptomatic LICA disease had greater risk of cognitive decline than other individuals, either measured by the Mini Mental State Examination score (F = 5.18, P - .002) or by the Clock Drawing Task score (F = 9.42, P = .001). Conclusions: Patients undergoing CE for symptomatic LICA disease appear to be at increased risk of cognitive decline than other individuals. Further studies are needed to confirm these findings and to evaluate whether LICA endarterectomy before occurrence of cerebrovascular ischemic symptoms may provide additive benefit in the prevention of cognitive decline.
机译：背景：尚未完全阐明在发生缺血性症状之前或之后因左颈内动脉（ICA）（LICA）疾病接受颈动脉内膜切除术（CE）的患者认知能力下降的风险。我们评估了有症状的LICA狭窄接受CE的患者是否比无症状LICA疾病或右ICA疾病的患者具有更大的认知下降风险。方法：在一系列65岁及以上的连续接受CE且无认知障碍的患者中，通过年龄和教育程度调整的迷你心理状态检查以及在基线结束时和末日进行的钟表绘制任务来评估认知功能。研究期间（平均随访时间：44.4±14.3个月）。结果：该分析包括103例患者（平均年龄72.6±7.0岁; 73例男性），其中50例患有LICA疾病（29例有症状）。在研究期结束时，有症状的LICA病患者（P <.001）的迷你心理状态检查评分降低，而其他患者则未降低，而LICA和右ICA的患者的时钟绘图任务评分均降低。有症状的LICA病患者的认知能力下降风险比其他个体更大，无论是通过迷你心理状态测验得分（F = 5.18，P-.002）还是通过Clock Drawing Task得分（F = 9.42，P = .001）衡量）。结论：有症状的LICA疾病接受CE的患者似乎比其他个体有更高的认知下降风险。需要进一步的研究来证实这些发现，并评估在发生脑血管缺血症状之前进行LICA内膜切除术是否可以在预防认知功能减退方面提供额外的益处。

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