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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Clinical correlating factors and cognitive function in community-dwelling healthy subjects with cerebral microbleeds
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Clinical correlating factors and cognitive function in community-dwelling healthy subjects with cerebral microbleeds

机译：社区居住的健康人脑微出血的临床相关因素和认知功能

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We performed brain gradient-echo T2*-weighted magnetic resonance imaging (GE-MRI) in community-dwelling healthy people to investigate the clinical correlates (i.e., possible risk factors) and cognitive function in subjects with cerebral microbleeds (MBs). We examined 368 healthy subjects age 39 years or older living in a Japanese rural community, performing baseline and clinical assessments and brain MRI (T2*-weighted, T1-weighted, T2-weighted, and FLAIR). We assessed global cognitive function in subjects age 60 years or older using the Mini-Mental State Examination (MMSE). An MMSE score >1.5 standard deviations (SD) below the mean score for a particular age group was considered subnormal. MBs were present in 14 of 368 subjects overall (3.8%; 11 males and 3 females) and in 14 of 225 subjects age ≥60 years (6.2%). In a logistic regression analysis, older age (odds ratio [OR] = 2.649/10 years; 95% confidence interval [CI] = 1.465-4.788) and male sex (OR = 6.876; 95% CI = 1.801-26.248) were significantly related to the presence of MBs. The presence of silent brain infarction and white matter lesions was correlated with MBs, suggesting that MBs were the consequence of small-vessel diseases. There was a significant association between the presence of MBs and subnormal cognition defined by MMSE (OR = 5.226; 95% CI = 1.463-18.662). Our data suggest that in healthy community-dwelling subjects, MBs may be a consequence of small-vessel disease, which is correlated with aging, male sex, and subnormal cognition.
机译：我们对居住在社区的健康人进行了脑梯度回波T2 *加权磁共振成像（GE-MRI），以研究脑微出血（MBs）患者的临床相关性（即可能的危险因素）和认知功能。我们检查了生活在日本农村社区中的368名年龄在39岁以上的健康受试者，进行了基线和临床评估以及脑MRI（T2 *加权，T1加权，T2加权和FLAIR）。我们使用迷你精神状态检查（MMSE）评估了60岁或60岁以上受试者的总体认知功能。低于特定年龄组平均得分的MMSE得分> 1.5标准偏差（SD）低于正常水平。总共368名受试者中有14名（3.8％; 11名男性和3名女性）出现了MB，225名年龄≥60岁的受试者中有14名（6.2％）存在MB。在逻辑回归分析中，年龄（比值比[OR] = 2.649 / 10年; 95％置信区间[CI] = 1.465-4.788）和男性（OR = 6.876; 95％CI = 1.801-26.248）显着与MB的存在有关。无症状性脑梗塞和白质病变的存在与MBs相关，表明MBs是小血管疾病的结果。 MB的存在与MMSE定义的亚正常认知之间存在显着关联（OR = 5.226; 95％CI = 1.463-18.662）。我们的数据表明，在健康的社区居民受试者中，MB可能是小血管疾病的结果，这与衰老，男性性别和不正常的认知有关。

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