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Bilateral medial medullary infarction: A systematic review

机译:双侧内侧髓样梗死:系统评价

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Bilateral infarction of the medial medulla (MMI) is rare. Limited information is available on clinical characteristics, etiology, and prognosis. High-resolution neuroimaging has a major role in elucidating the underlying stroke mechanism. The aim of this systematic review was to analyze the clinical presentations, stroke mechanisms, and outcomes in patients with bilateral MMI. We performed a systematic review of the literature from 1992-2011 that reported on clinical presentations, stroke mechanism, and/or outcomes in patients with magnetic resonance imaging-proven bilateral MMI. Medline, EMBASE, and Web of Science Scholars Portal were searched without language restriction. Two reviewers independently assessed identified studies to determine eligibility, validity, and quality. The primary outcome was inpatient mortality; a secondary outcome was case fatality at 12 months. We identified 138 articles from Medline, EMBASE, and Scholars Portal including the MeSH terms "brainstem infarction," "medulla," and "bilateral." Twenty-nine articles met our inclusion criteria, including a total of 38 cases with bilateral MMI, and included in our study. These 38 patients had a mean age of 62.2 years and were predominately male (74.2%). The most common clinical presentations were motor weakness in 78.4%, dysarthria in 48.6%, and hypoglossal palsy in 40.5%. The most common vascular pathology was vertebral artery atherosclerosis, in 38.5%. The clinical outcome was poor (mortality, 23.8%; dependency, 61.9%). Bilateral medial medullary infarction is a rare stroke syndrome. Clinical presentations were mostly rostral medullary lesions. Large-artery atherosclerosis and branch disease were the most common stroke mechanisms. The clinical outcome was usually poor.
机译:内侧延髓(MMI)的双侧梗塞罕见。关于临床特征,病因和预后的信息有限。高分辨率神经影像学在阐明潜在的中风机制中起主要作用。该系统评价的目的是分析双侧MMI患者的临床表现,中风机制和预后。我们对1992年至2011年的文献进行了系统的回顾,该文献报道了经磁共振成像证实的双侧MMI患者的临床表现,中风机制和/或预后。不受语言限制地搜索Medline,EMBASE和Web of Science门户网站。两名审稿人独立评估已确定的研究以确定资格,有效性和质量。主要结果是住院死亡率。次要结果是12个月时病死率。我们从Medline,EMBASE和Scholars Portal中找到了138篇文章,其中包括MeSH术语“脑干梗塞”,“髓质”和“双边”。有29篇文章符合我们的纳入标准,包括总共38例双侧MMI病例,并纳入了我们的研究。这38例患者的平均年龄为62.2岁,其中以男性占多数(74.2%)。最常见的临床表现是运动无力78.4%,构音障碍48.6%和舌下神经麻痹40.5%。最常见的血管病理是椎动脉粥样硬化,占38.5%。临床结果差(死亡率为23.8%;依存度为61.9%)。双侧内侧髓样梗塞是一种罕见的中风综合征。临床表现主要为延髓延髓病变。大动脉粥样硬化和分支疾病是最常见的中风机制。临床结果通常较差。

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