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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Association of Stroke Clinical Outcomes with Coexistence of Hyperglycemia and Biomarkers of Inflammation
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Association of Stroke Clinical Outcomes with Coexistence of Hyperglycemia and Biomarkers of Inflammation

机译：中风临床结果与高血糖和炎症生物标志物共存的关联

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Background: To investigate the association of short-term clinical outcomes with coexistence of hyperglycemia and elevated biomarkers of inflammation among acute ischemic stroke (AIS) patients. Methods: We performed a retrospective study of 2675 patients diagnosed with AIS from January 2006 to December 2008. The study outcomes were defined as neurologic deficiency (National Institutes of Health Stroke Scale score >= 5) at discharge or death during hospitalization. Results: Compared with normoglycemia and without any elevated biomarkers, patients with hyperglycemia, elevated white blood cell (WBC) count, elevated neutrophils ratio (NEUR), and elevated erythrocyte sedimentation rate (ESR) had higher rates of study outcomes (all P < .05). Furthermore, patients with coexistence of hyperglycemia with any of elevated WBC count, NEUR, or ESR were more likely to have study outcomes (all P < .05). Compared with subjects with normoglycaemia and without any elevated biomarker, multivariate adjusted odds ratios (95% confidence interval) of study outcomes associated with hyperglycemia, elevated WBC count, elevated NEUR, elevated ESR, coexistences of hyperglycemia with elevated WBC count, elevated NEUR, and elevated ESR were 1.492 (1.139-1.955), 1.404 (1.048-1.881), 1.897 (1.411-2.551), 2.184 (1.339-3.564), 1.963 (1.337-2.883), 2.544 (1.715-3.775), and 2.687 (1.347-5.363), respectively. Conclusions: This study indicated that hyperglycemia and elevated biomarkers of inflammation were associated with short-term clinical outcomes, and individuals with coexistence of hyperglycemia and elevated biomarkers of inflammation had higher risk of poor clinical outcomes among AIS patients.
机译：背景：探讨短期临床结果与急性缺血性中风（AIS）患者高血糖和炎症生物标志物共存的关系。方法：我们对2006年1月至2008年12月诊断为AIS的2675例患者进行了回顾性研究。研究结果被定义为住院期间出院或死亡时的神经系统缺陷（美国国立卫生研究院卒中量表评分> = 5）。结果：与正常血糖相比，没有任何生物标志物升高的患者，高血糖，白细胞（WBC）计数升高，中性粒细胞比率（NEUR）升高和红细胞沉降率（ESR）升高的患者的研究结局更高（所有P <。 05）。此外，高血糖并存且WBC计数，NEUR或ESR升高的患者更有可能获得研究结果（所有P <.05）。与患有高血糖症且没有任何生物标志物升高的受试者相比，与高血糖症，WBC计数升高，NEUR升高，ESR升高，高血糖与WBC计数升高，NEUR升高和高血糖症共存相关的研究结局的多元校正比值比（95％置信区间）高ESR为1.492（1.139-1.955），1.404（1.048-1.881），1.897（1.411-2.551），2.184（1.339-3.564），1.963（1.337-2.883），2.544（1.715-3.775）和2.687（1.347- 5.363）。结论：这项研究表明高血糖和炎症生物标志物升高与短期临床预后相关，高血糖和炎症生物标志物并存的个体在AIS患者中临床预后不良的风险更高。

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