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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Repeated Transient Wallenberg's Syndrome: Probable Association with Ipsilateral Vertebral Artery Hypoplasia and Aortic Valve Disease
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Repeated Transient Wallenberg's Syndrome: Probable Association with Ipsilateral Vertebral Artery Hypoplasia and Aortic Valve Disease

机译：反复的短暂性Wallenberg综合征：与同侧椎动脉发育不全和主动脉瓣疾病的可能关联

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Background: Here we report a rare case of repeated transient Wallenberg's syndrome and discuss its mechanism. Methods: Case report and literature review. Results: A 57-year-old man was admitted for 1.5-month repeated transient Wallenberg's syndrome, including right-sided Horner's syndrome, lower limb weakness, and paresthesia on the right side of the body and face. His symptom appeared mostly during physical activity. Symptoms occurred nearly everyday and lasted from 5 minutes to 30 minutes. His cranial magnetic resonance imaging (MRI) including diffusion-weighted MRI imaging was normal, and his cervical contrast-enhanced magnetic resonance angiography reflected right vertebral artery hypoplasia. Twenty-four-hour electrocardiogram and electroencephalography showed no abnormalities. Echocardiography showed aortic valve calcification with moderate aortic stenosis, moderate aortic insufficiency, and dilated aorta. Dual-antiplatelets or warfarin (international normalized ratio reached 2.07) were not effective to reduce the attacks. Conclusions: Hemodynamic instability due to valve disease combined with right vertebral artery hypoplasia could lead to transient Wallenberg's syndrome. Antithrombotics are often ineffective for this kind of patients and the best therapy for them could be to cure their valve disease. Repeated transient Wallenberg's syndrome is rare and that caused by ipsilateral vertebral artery hypoplasia and severe valve disease has not been reported up till now to our knowledge, so it will widen the knowledge on etiologies of transient ischemic attacks and provide information and reference to cardiologists and neurologists in diagnosis and treatment for patients with similar clinical manifestations.
机译：背景：在这里我们报告了罕见的反复发作的短暂性瓦伦贝格综合症病例，并讨论了其机制。方法：病例报告和文献复习。结果：一名57岁的男子因反复出现的1.5个月短暂性Wallenberg综合征而入院，其中包括右侧的Horner综合征，下肢无力以及身体和面部右侧的感觉异常。他的症状主要出现在体育锻炼中。症状几乎每天发生，持续5分钟到30分钟。他的包括弥散加权MRI在内的颅骨磁共振成像（MRI）正常，而他的颈椎造影增强磁共振血管造影反映了右椎动脉发育不全。 24小时心电图和脑电图未见异常。超声心动图显示主动脉瓣钙化伴有中度主动脉瓣狭窄，中度主动脉瓣关闭不全和主动脉扩张。双重抗血小板药或华法林（国际标准化比例达到2.07）不能有效减少发作。结论：由于瓣膜疾病引起的血流动力学不稳定并伴有右椎动脉发育不全可能导致短暂的Wallenberg综合征。抗血栓药通常对这类患者无效，对他们来说最好的治疗方法可能是治愈其瓣膜疾病。据我们所知，反复的短暂性Wallenberg综合征很少见，而由同侧椎动脉发育不全和严重的瓣膜疾病引起的综合征至今尚未报道，因此它将拓宽关于短暂性缺血发作病因的知识，并为心脏病学家和神经病学家提供信息和参考。在诊治中具有相似临床表现的患者。

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