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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Arterial Spin Labeling Perfusion Magnetic Resonance Image with Dual Postlabeling Delay: A Correlative Study with Acetazolamide Loading I-123-Iodoamphetamine Single-Photon Emission Computed Tomography
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Arterial Spin Labeling Perfusion Magnetic Resonance Image with Dual Postlabeling Delay: A Correlative Study with Acetazolamide Loading I-123-Iodoamphetamine Single-Photon Emission Computed Tomography

机译：具有双重后标记延迟的动脉自旋标记灌注磁共振图像：乙酰唑胺负载I-123-碘苯丙胺单光子发射计算机断层扫描的相关性研究

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Background: Perfusion magnetic resonance image with arterial spin labeling (ASL) provides a completely noninvasive measurement of cerebral blood flow (CBF). However, arterial transient times can have a marked effect on the ASL signal. For example, a single postlabeling delay (PLD) of 1.5 seconds underestimates the slowly streaming collateral pathways that maintain the cerebrovascular reserve (CVR). To overcome this limitation, we developed a dual PLD method. Subjects and methods: A dual PLD method of 1.5 and 2.5 seconds was compared with I-123-iodoamphetamine single-photon emission computed tomography with acetazolamide loading to assess CVR in 10 patients with steno-occlusive cerebrovascular disease. Results: In 5 cases (Group A), dual PLD-ASL demonstrated low CBF with 1.5-second PLD in the target area, whereas CBF was improved with 2.5-second PLD. In the other 5 cases (Group B), dual PLD-ASL depicted low CBF with 1.5-second PLD, and no improvement in CBF with 2.5-second PLD in the target area was observed. On single-photon emission computed tomography, CVR was maintained in Group A but decreased in Group B. Conclusions: Although dual PLD methods may not be a completely alternative test for I-123-iodoamphetamine single-photon emission computed tomography with acetazolamide loading, it is a feasible, simple, noninvasive, and repeatable technique for assessing CVR, even when employed in a routine clinical setting.
机译：背景：带有动脉自旋标记（ASL）的灌注磁共振图像提供了脑血流（CBF）的完全无创测量。但是，动脉瞬变时间可能会对ASL信号产生显着影响。例如，单个标记后延迟（PLD）为1.5秒，低估了维持脑血管储备（CVR）的缓慢流动的侧支通路。为了克服此限制，我们开发了双重PLD方法。对象和方法：将1.5秒和2.5秒的双重PLD方法与I-123-碘安非他命单光子发射计算机断层显像和乙酰唑胺负荷量进行比较，以评估10例狭窄性闭塞性脑血管疾病患者的CVR。结果：在5例病例（A组）中，双重PLD-ASL表现出目标区域CBF低且1.5秒PLD，而CBF改善了2.5秒PLD。在其他5种情况下（B组），双PLD-ASL在1.5秒的PLD时显示低CBF，而在目标区域中观察到2.5秒的PLD时CBF没有改善。在单光子发射计算机体层摄影术中，A组中的CVR保持不变，但在B组中下降。即使在常规临床环境中使用，也是一种评估CVR的可行，简单，无创且可重复的技术。

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