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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Early Predictors of Fever in Patients with Aneurysmal Subarachnoid Hemorrhage
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Early Predictors of Fever in Patients with Aneurysmal Subarachnoid Hemorrhage

机译：动脉瘤性蛛网膜下腔出血患者发烧的早期预测因子

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Background: Fever is commonly observed in patients who have had aneurysmal subarachnoid hemorrhage (SAH), and it has been associated with the occurrence of delayed cerebral ischemia and worse outcomes in previous studies. Frequently, fever is not the result of bacterial infections, and distinction between infectionrelated fever and fever secondary to brain injury (also referred as central fever) can be challenging. Objectives: The current study aimed to identify risk factors on admission for the development of central fever in patients with SAH. Methods: Databank analysis was performed using information from demographic data (age, gender), imaging (transcranial Doppler ultrasound, computed tomography, and cerebral angiogram), laboratory (white blood cell count, hemoglobin, renal function, and electrolytes), and clinical assessment (Hunt-Hess and modified Fisher scales on admission, occurrence of fever). A multivariate logistic regression model was created. Results: Of 55 patients, 32 developed fever during the first 7 days of hospital stay (58%). None of the patients had identifiable bacterial infections during their first week in the neurocritical care unit. Hunt-Hess scale > 2 and leukocytosis on admission were associated to the development of central fever, even after correction in a logistic regression model. Conclusion: Leukocytosis and a poor neurologic examination on admission might help predict which subset of patients with SAH are at higher risk of developing central fever early in their hospital stay.
机译：背景：在患有动脉瘤性蛛网膜下腔出血（SAH）的患者中通常观察到发烧，在先前的研究中，它与迟发性脑缺血的发生和预后差有关。通常，发烧不是细菌感染的结果，与感染相关的发烧和脑损伤继发的发烧（也称为中枢发烧）之间的区别可能具有挑战性。目的：本研究旨在确定SAH患者中枢性发烧入院的危险因素。方法：使用人口统计数据（年龄，性别），影像学（经颅多普勒超声，计算机断层扫描和脑血管造影），实验室（白细胞计数，血红蛋白，肾功能和电解质）和临床评估中的信息进行数据库分析（Hunt-Hess和改良的Fisher量表用于入院，发烧）。建立了多元逻辑回归模型。结果：55名患者中，有32名在住院的前7天发烧（58％）。在神经重症监护病房的第一周，没有患者出现可识别的细菌感染。即使在逻辑回归模型中校正后，Hunt-Hess评分> 2和入院时白细胞增多也与中枢发烧的发生有关。结论：白细胞增多症和入院时神经系统检查不佳可能有助于预测哪些SAH患者亚组在住院期间发生中枢发热的风险更高。

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