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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Prediction of ischemic stroke in patients with tissue-defined transient ischemic attack
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Prediction of ischemic stroke in patients with tissue-defined transient ischemic attack

机译：组织定义的短暂性脑缺血发作患者缺血性卒中的预测

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Background The risk of future stroke after transient ischemic attack (TIA) has been widely studied, but most findings were obtained for classically defined TIA (time-defined TIA). A new definition of TIA, that is, tissue-defined TIA, which requires the absence of fresh brain infarction on magnetic resonance imaging, could change stroke risk assessments. We, therefore, aimed to evaluate the risk of future stroke in patients with tissue-defined TIA. Methods We retrospectively reviewed 74 patients with tissue-defined TIA, who could be followed for 2 years. Clinical, laboratory, and radiological data were collected and compared between groups that did and did not develop ischemic stroke within the 2-year period. Results Ischemic stroke occurred in 11 patients (14.9%). Increased age, hemiparesis, and/or dysarthria during the TIA, old cerebral infarction revealed by magnetic resonance imaging, and large-artery stenosis detected by magnetic resonance angiography and/or ultrasonography tended to increase the risk of future stroke, but no individual factor showed statistically significant effect. TIA etiology did not significantly affect the risk. ABCD2 score, an established score for predicting stroke after time-defined TIA, showed only a weak association with future stroke. In contrast, new scores that we created reliably predicted future stroke; these included the APO (age, paresis, and old cerebral infarction) and APOL (age, paresis, old cerebral infarction, and large-artery stenosis) scores. The areas under the receiver operating characteristic curves were.662,.737, and.807 for ABCD2, APO, and APOL, respectively. Conclusions Compared with the established measures, our newly created scores could predict future stroke for tissue-defined TIA more reliably.
机译：背景技术已经广泛研究了短暂性脑缺血发作（TIA）后未来中风的风险，但是大多数发现是针对经典定义的TIA（时间定义的TIA）获得的。 TIA的新定义，即组织定义的TIA，需要在磁共振成像中没有新鲜的脑梗塞，可能会改变中风风险评估。因此，我们旨在评估组织界定的TIA患者未来中风的风险。方法我们回顾性分析了74例组织明确的TIA患者，可以随访2年。收集临床，实验室和放射学数据，并对在2年内未发生缺血性卒中的组之间进行比较。结果11例发生缺血性中风（14.9％）。 TIA期间年龄，偏瘫和/或构音障碍增加，磁共振成像显示脑梗塞变老，磁共振血管造影和/或超声检查发现大动脉狭窄倾向于增加未来中风的风险，但未显示个体因素具有统计学意义的效果。 TIA病因没有显着影响风险。 ABCD2评分是在时间定义的TIA后预测卒中的既定评分，显示与未来卒中的关联较弱。相反，我们创建的新分数可以可靠地预测未来的卒中。其中包括APO（年龄，轻瘫，老龄脑梗塞）和APOL（年龄，轻瘫，老龄脑梗塞和大动脉狭窄）评分。对于ABCD2，APO和APOL，接收机工作特性曲线下的面积分别为.662，.737和.807。结论与已建立的措施相比，我们新创建的评分可以更可靠地预测组织定义的TIA的未来卒中。

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