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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >HindIII polymorphism in the lipoprotein lipase gene and hypertensive intracerebral hemorrhage in the Chinese Han population
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HindIII polymorphism in the lipoprotein lipase gene and hypertensive intracerebral hemorrhage in the Chinese Han population

机译：汉族人群脂蛋白脂肪酶基因HindIII多态性与高血压脑出血

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Background To investigate the relationship between the HindIII polymorphism and hypertensive intracerebral hemorrhage (HIH) and lipid metabolism. Methods A polymerase chain reaction-restriction fragment length polymorphism assay and the chain termination DNA sequencing method were used to determine the HindIII genotypes of 267 subjects, which included 120 cerebral hemorrhagic patients and 147 controls. The fasting levels of lipids and glucose in the plasma were used to measure the effect of genotype on HIH risk factors. Results The frequency of the T allele of the HindIII polymorphism in the HIH group was 90.8%. The frequency of the G allele was 9.2%. In the control group, the frequencies were 82.3% T and 17.7% G, which indicated that the proportion of the G allele in the HIH patient group was significantly lower than in the control group (P <.05). The frequency of GG + GT genotypes in HIH patients (P <.05) and the plasma triglyceride (TG) levels in these patients (P <.05) were also lower than in the control group. The levels of plasma TG, low-density lipoprotein cholesterol, glucose, systolic blood pressure, and diastolic blood pressure in the HIH group were higher than in the controls (P <.05). After controlling for risk factors related to HIH, the HindIII G allele was negatively correlated with the incidence of HIH (odds ratio =.417, 95% confidence interval:.193-.901). Conclusions The HindIII G allele may be a protective factor against the development of HIH among the Han Chinese population.
机译：背景研究HindIII基因多态性与高血压脑出血（HIH）和脂质代谢之间的关系。方法采用聚合酶链反应-限制性片段长度多态性分析法和链终止DNA测序法确定267例受试者的HindIII基因型，包括120例脑出血患者和147例对照。血浆中脂质和葡萄糖的禁食水平用于测量基因型对HIH危险因素的影响。结果HIH组HindIII多态性的T等位基因频率为90.8％。 G等位基因的频率为9.2％。在对照组中，频率为82.3％T和17.7％G，这表明HIH患者组中G等位基因的比例显着低于对照组（P <.05）。 HIH患者的GG + GT基因型频率（P <.05）和这些患者的血浆甘油三酸酯（TG）水平（P <.05）也低于对照组。 HIH组血浆TG，低密度脂蛋白胆固醇，葡萄糖，收缩压和舒张压的水平高于对照组（P <.05）。在控制了与HIH相关的危险因素后，HindIII G等位基因与HIH的发生率呈负相关（几率= .417，95％置信区间：.193-.901）。结论HindIII G等位基因可能是中国汉族人群HIH发生发展的保护因素。

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