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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Seasonal Differences and Circadian Variation in Stroke Occurrence and Stroke Subtypes
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Seasonal Differences and Circadian Variation in Stroke Occurrence and Stroke Subtypes

机译：中风发生和中风亚型的季节性差异和昼夜节律变化

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Background: India is a subtropical country with clear seasonal variations in weather conditions. Seasonal and circadian variation in occurrence of subtypes of cerebrovascular disease has been of interest in several studies from different countries and climate zones, but discrepant results have made the conclusions unclear. The aim of the present study was to observe the seasonal and circadian variation in the occurrence of stroke and its subtypes among our population. Methods: This was a cross-sectional observational study based on new cases and past cases of stroke on follow-up, conducted between January 2011 and December 2012 in the Department of Neurology, at the All India Institute of Medical Sciences, New Delhi, India. The date and time of onset of the stroke was recorded. The categorization of months into season was in accordance with the Indian Meteorological Department guidelines. The time of onset was distributed into 6 hourly intervals. Statistical calculations were performed using Stata version 12.1 and SPSS version 20. Results: A total of 583 patients were included for the study. The rate of occurrence of stroke was highest in the late morning 0600-1159 hours (P value,. 001) compared with other times of the day, regardless of gender or age for both ischemic and hemorrhagic strokes. It was lowest in late evening (1800-2359 hours) quadrant compared with other quadrants. Although there was no significant difference found by dichotomizing the groups into two 6-month periods, there was an increasing trend in number of patients with stroke during the months November-February. There was no difference in stroke occurrence between the types of stroke or within each type among different seasons with different temperatures. Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification of ischemic strokes also did not show any association with season or circadian rhythm. Conclusions: There is a significant increase in occurrence of strokes between 0600 and 1159 hours and lowest between 1800-2359 hours. No significant variation in stroke occurrence or subtype for any of the seasons was observed.
机译：背景：印度是一个亚热带国家，天气状况季节性明显变化。来自不同国家和气候区的几项研究都关注了脑血管疾病亚型的季节性和昼夜节律变化，但是不同的结果使结论尚不清楚。本研究的目的是观察我国人群中风及其亚型发生的季节和昼夜节律变化。方法：这是一项横断面观察性研究，该研究基于随访的新病例和既往中风病例，于2011年1月至2012年12月在印度新德里全印度医学科学研究所神经内科进行。 。记录中风发作的日期和时间。按季节划分的月份分类符合印度气象局的指南。发病时间分为6小时间隔。使用Stata版本12.1和SPSS版本20进行统计计算。结果：研究共纳入583名患者。与一天中的其他时间相比，在早上060至1159小时内，中风的发生率最高（P值，。001），而不论缺血性和出血性中风的性别或年龄如何。与其他象限相比，它在傍晚（1800-2359小时）象限中最低。尽管将两组分为两个6个月的时期并没有发现显着差异，但在11月至2月的几个月中，中风患者的数量却呈上升趋势。中风类型之间或中风温度不同的不同季节中每种类型的中风发生没有差异。 Org 10172在缺血性中风的急性中风治疗（TOAST）分类中的试验也未显示与季节或昼夜节律有关。结论：0600至1159小时之间的中风发生率显着增加，而1800-2359小时之间的中风发生率则最低。在任何季节中，均未观察到卒中发生或亚型的显着变化。

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