...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >The Combination of Clinical Features, Transcranial Doppler, and Alberta Stroke Program Early Computed Tomography Score (Computed Tomography Angiography) in Predicting Outcome in Intravenous Recombinant Tissue Plasminogen Activator-Treated Patients
【24h】

The Combination of Clinical Features, Transcranial Doppler, and Alberta Stroke Program Early Computed Tomography Score (Computed Tomography Angiography) in Predicting Outcome in Intravenous Recombinant Tissue Plasminogen Activator-Treated Patients

机译：临床特征，经颅多普勒检查和艾伯塔中风计划早期计算机断层扫描评分（计算机断层扫描血管造影）的组合，用于预测静脉内重组组织纤溶酶原激活剂治疗患者的结果

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Little data exist on using combined baseline clinical neuroimaging and transcranial Doppler (TCD) information in predicting clinical outcome in stroke patients treated with intravenous (IV) thrombolysis. Methods: Stroke patients received IV recombinant tissue plasminogen activator (rt-PA) and had diagnostic TCD within 3 hours of symptom onset. The TCD result was interpreted using the thrombolysis in brain ischemia (TIBI) flow grading system. Following multiple regression analysis, a grading system was created with 1 point for each of the following: National Institutes of Health Stroke Scale (NIHSS) score of 16 or higher, TIBI score of 1 or lower, and Alberta Stroke Program Early CT Score (ASPECTS) of 6 or lower. The patients' scores were compared to modified Rankin Scale (mRS) scores at 90 days. Results: A total of 349 patients were included. In unvaried analysis, age of 80 years or older (P = .002), an ASPECTS of 6 or lower (P < .001), an NIHSS score of 16 or higher (P < .001), a TIBI score of 1 or lower (P < .001), and a glucose level >= 200 mg/dl (P = .04) were associated with poor outcome (mRS score > 2). In the multiple regression analysis, age of 80 years or older, an ASPECTS of 6 or lower, an NIHSS score of 16 or higher, and hyperglycemia were predictors of poor outcome (P < .05). Based on our scoring system, the patients' odds ratios for poor outcome were 7 (95% confidence interval [CI]: 2-23, P = .003), 8 (95% CI: 3-25, P < .001), and 24 (95% CI: 4-151, P = .001) for scores of 1, 2, and 3, respectively, after adjustment for common stroke risk factors. The mean time to recanalization increased as the score increased (score of 0: 160 +/- 45 minutes versus score of 3: 186 > 38 (P = .70). Conclusion: A multimodal grading system is useful in predicting outcome in patients treated with IV rt-PA. Those with higher scores might be candidates for interventional therapy.
机译：背景：关于使用基线临床神经影像学和经颅多普勒（TCD）信息相结合来预测接受静脉溶栓治疗的卒中患者的临床结局的资料很少。方法：中风患者接受IV重组组织纤溶酶原激活剂（rt-PA），并在症状发作后3小时内诊断为TCD。使用脑缺血溶栓（TIBI）血流分级系统解释TCD结果。经过多元回归分析，为以下各项创建了一个评分系统，每个评分1分：美国国立卫生研究院卒中量表（NIHSS）得分为16或更高，TIBI得分为1或更低以及艾伯塔省卒中计划早期CT得分（ASPECTS） ）等于或小于6。在90天时将患者评分与改良的Rankin量表（mRS）评分进行比较。结果：共纳入349例患者。在无变量分析中，年龄为80岁或以上（P = .002），ASPECTS为6或更低（P <.001），NIHSS得分为16或更高（P <.001），TIBI得分为1或较低（P <.001）和葡萄糖水平> = 200 mg / dl（P = .04）与不良预后相关（mRS评分> 2）。在多元回归分析中，年龄为80岁或以上，ASPECTS为6或更低，NIHSS得分为16或更高以及高血糖是不良预后的预测因素（P <.05）。根据我们的评分系统，患者不良结局的优势比为7（95％置信区间[CI]：2-23，P = .003），8（95％CI：3-25，P <.001）调整常见卒中危险因素后，分别获得1、2和3的评分分别为24和（95％CI：4-151，P = .001）。重新通气的平均时间随着得分的增加而增加（得分为0：160 +/- 45分钟，得分为3：186> 38（P = 0.70）。结论：多模式评分系统可用于预测接受治疗的患者的预后IV rt-PA评分较高者可能是介入治疗的候选人。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号