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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Cognitive Outcomes following Thrombolysis in Acute Ischemic Stroke: A Systematic Review
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Cognitive Outcomes following Thrombolysis in Acute Ischemic Stroke: A Systematic Review

机译：急性缺血性卒中溶栓后的认知结果：系统评价

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Background: Patients treated with thrombolytic therapy within 4.5 hours after stroke onset appear to have improved survival and functional outcomes. Poststroke cognitive impairment is associated with reduced quality of life and survival and needs to be reviewed in consideration of the administration of thrombolysis. This review aims to systematically evaluate literature exploring the effect of thrombolysis for ischemic stroke on cognition. Methods: An electronic search was conducted to identify articles and gray literature applying broad Medical Subject Heading terms. Literature was reviewed with a 2-step process against predetermined inclusion criteria. All relevant studies were included if they investigated global or individual cognitive domains. Results: Three studies satisfied the inclusion criteria but were diverse in outcome measures and duration, their heterogeneity limiting any possible pooled analysis. One study examined long-term treatment effects on global cognition and did not find a positive effect at 6 months. A positive treatment effect was reported in the acute phase in 1 study examining domains of visuoconstructive and perceptive abilities. One study retrospectively analyzed treatment effects on language and found improvement in the acute phase but not in the long term. Conclusions: The limited existing evidence on the effects of thrombolytic therapy on long-and short-term cognition is varied in both outcome measures and diagnostic classifications, making it difficult to extrapolate results to a global stroke population. This review should be used to inform future research in stroke treatment outcomes and highlights the immediate need for larger, more robust studies in this area.
机译：背景：中风发作后4.5小时内接受溶栓治疗的患者似乎具有改善的生存和功能结局。脑卒中后认知功能障碍与生活质量和生存质量下降有关，需要考虑溶栓治疗的情况进行审查。这篇综述旨在系统地评估文献，探讨溶栓治疗缺血性中风对认知的影响。方法：进行电子搜索以识别使用广泛医学主题词的文章和灰色文献。按照预定的纳入标准，通过两步过程对文献进行审查。如果他们调查了全局或单个认知领域，则将所有相关研究包括在内。结果：三项研究均符合纳入标准，但结局指标和持续时间各不相同，其异质性限制了所有可能的汇总分析。一项研究检查了长期治疗对整体认知的影响，但在6个月时未发现阳性反应。在一项研究中，报告了在急性期的积极治疗效果，该研究检查了视力建设和感知能力的领域。一项研究回顾性分析了治疗对语言的影响，发现在急性期有所改善，但长期没有改善。结论：关于溶栓治疗对长期和短期认知影响的现有证据有限，在结局指标和诊断分类上均存在差异，因此难以将结果推算至全球卒中人群。该综述应用于为中风治疗结局的未来研究提供信息，并强调当前对该领域更大，更可靠的研究的迫切需求。

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