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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Withdrawal of Antithrombotic Agents and the Risk of Stroke
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Withdrawal of Antithrombotic Agents and the Risk of Stroke

机译：停用抗血栓药和中风的风险

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Background and Purpose: Antithrombotic medications are effective for ischemic stroke prevention, but stoppage of these medications is associated with an increased risk of thromboembolism. The frequency of antithrombotic withdrawal in the general population is unknown. Methods: We conducted a random phone sample of 2036 households in the Greater Cincinnati metropolitan area, representative of the stroke population by age, sex, and race, to determine the frequency of antithrombotic medication use and stoppage by physicians for medically indicated procedures. Results: Sixty-two percent of survey respondents reported that they were on an antithrombotic medication. Ten percent of participants reported that they had stopped taking their medication within the past 60 days for a medically indicated intervention. Of those who stopped taking the medication, it was more common for persons taking an anticoagulant to stop their medication (20%) than those taking an antiplatelet agent (9%). Colonoscopies and orthopedic surgeries were the most common reasons for withdrawal of antiplatelet agents, whereas orthopedic and vascular surgeries were the most common reason for withdrawal of anticoagulants. Conclusions: Recommended discontinuation of antithrombotic medication for surgical or diagnostic procedures is common practice for persons in the community representative of a stroke population. Because stoppage of these medications is associated with an increased risk of thromboembolic stroke, further clinical trials are needed to determine best management practices in this setting.
机译：背景与目的：抗血栓药物可有效预防缺血性中风，但停止使用这些药物会增加血栓栓塞的风险。一般人群中抗血栓形成戒断的频率未知。方法：我们对大辛辛那提大都会地区的2036户家庭进行了电话随机抽样，以年龄，性别和种族代表中风人口，以确定抗血栓药物的使用频率以及医生针对医学上指明的程序而停药的频率。结果：62％的调查受访者表示他们正在服用抗血栓药物。百分之十的参与者报告说，在过去60天内，他们出于医学上的干预措施已经停止服药。在那些停止服用药物的人中，服用抗凝剂的人（20％）比服用抗血小板药的人（9％）更常见。结肠镜检查和整形外科手术是停用抗血小板药的最常见原因，而骨科和血管外科手术是停用抗凝剂的最常见原因。结论：对于中风人群的社区代表，建议通过外科手术或诊断程序停止使用抗血栓药物。由于停止使用这些药物会增加血栓栓塞性中风的风险，因此需要进一步的临床试验以确定这种情况下的最佳管理方法。

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