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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Endothelial Function, Inflammation, Thrombosis, and Basal Ganglia Perivascular Spaces in Patients with Stroke
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Endothelial Function, Inflammation, Thrombosis, and Basal Ganglia Perivascular Spaces in Patients with Stroke

机译：脑卒中患者的内皮功能，炎症，血栓形成和基底节周围血管间隙

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Background and Objective: Recent studies suggest perivascular spaces are a marker of small vessel disease, blood-brain barrier permeability, and inflammation, but little is known about their risk factors and associations with peripheral blood markers. Materials and Methods: In prospectively recruited patients with recent minor ischemic stroke, we investigated the influence of age, sex, hypertension, diabetes, and smoking on the severity of perivascular spaces in the basal ganglia seen on T2-weighted magnetic resonance imaging. We assessed plasma markers of endothelial function (von Willebrand factor, intracellular adhesion molecule-1), inflammation (interleukin-6, tumor necrosis factor-alpha, C-reactive protein), and thrombosis (fibrinogen, prothrombin fragments 1 + 2, thrombin-antithrombin complex, tissue plasminogen activator, D-dimer). We used a validated semi-automated method to measure basal ganglia perivascular spaces count and volume. We tested uni- and multivariable associations between blood markers and basal ganglia perivascular spaces count and volume. Findings: In 100 patients (median age: 67 years, range: 37-92), on adjusted analysis, basal ganglia perivascular spaces count was associated with age (r = .117, P = .003) and hypertension (r = 2.225, P = .013). On multivariable linear regression, adjusted for age, sex, hypertension, smoking and diabetes, reduced von Willebrand factor was associated with increased basal ganglia perivascular spaces count (r = -.025, P = .032). Conclusion: The association of increased basal ganglia perivascular spaces count with reduced von Willebrand factor is novel. As von Willebrand factor may promote cerebral endothelial integrity, insufficient von Willebrand factor is consistent with dysfunctional cerebral endothelium and increased basal ganglia perivascular spaces in cerebral small vessel disease. Quantitative perivascular spaces measurement may increase sensitivity to detect cerebral endothelial dysfunction.
机译：背景与目的：最近的研究表明，血管周间隙是小血管疾病，血脑屏障通透性和炎症的标志物，但对其危险因素以及与外周血标志物的关系知之甚少。资料和方法：我们在T2加权磁共振成像中观察了年龄，性别，高血压，糖尿病和吸烟对基底神经节血管周间隙的严重性的影响，对预期招募的近期有轻微缺血性中风的患者进行了研究。我们评估了内皮功能（血管性血友病因子，细胞内粘附分子-1），炎症（白介素-6，肿瘤坏死因子-α，C反应蛋白）和血栓形成（纤维蛋白原，凝血酶原片段1 + 2，凝血酶-抗凝血酶复合物，组织纤溶酶原激活物，D-二聚体）。我们使用一种经过验证的半自动化方法来测量基底神经节血管周围空间的数量和体积。我们测试了血液标志物与基底神经节血管周围空间计数和体积之间的单变量和多变量关联。研究结果：在100例患者（中位年龄：67岁，范围：37-92岁）中，经校正后的分析显示，基底节周围血管间隙计数与年龄（r = .117，P = .003）和高血压（r = 2.225， P = .013）。在对年龄，性别，高血压，吸烟和糖尿病进行校正的多变量线性回归分析中，von Willebrand因子降低与基底神经节血管周围空间增加相关（r = -.025，P = .032）。结论：增加的基底神经节周围血管空间计数与减少的von Willebrand因子相关。由于von Willebrand因子可促进脑内皮完整性，因此von Willebrand因子不足与脑小血管疾病中的脑内皮功能异常和基底神经节周围血管空间增加有关。定量血管周间隙测量可增加检测脑内皮功能障碍的敏感性。

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