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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Spontaneous Bilateral Cervical Internal Carotid and Vertebral Artery Dissection in a Japanese Patient without Collagen Vascular Disease with pecial Reference to Single-Nucleotide Polymorphisms
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Spontaneous Bilateral Cervical Internal Carotid and Vertebral Artery Dissection in a Japanese Patient without Collagen Vascular Disease with pecial Reference to Single-Nucleotide Polymorphisms

机译：一名无胶原血管疾病的日本患者的自发性双侧颈内颈和椎动脉夹层，特别提及单核苷酸多态性

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摘要

Spontaneous cervical artery dissection (sCAD) is a major cause of ischemic stroke in young adults. Frequently, sCAD involves multiple neck arteries, accounting for 13%-28% of the total sCAD cases. However, little is known about factors related to multiple sCAD. In this case, a 52-year-old man was admitted due to headache without aura. There was a personal history of migraine with aura and a family history of similar symptoms. The patient's younger brother had a left vertebral artery (VA) dissecting aneurysm and underwent endovascular occlusion of his parent artery at the age of 48. Magnetic resonance imaging of our admitted patient showed hyperintensities in the right internal carotid artery (ICA) without acute infarction, and magnetic resonance angiography revealed a narrowing of the right ICA. Angiography was then performed, which showed a trace of dissection of the left ICA and both VAs as well as the right ICA. The patient did not fulfill any major criteria of collagen vascular disease such as Ehlers-Danlos syndrome type IV or Loeys-Dietz syndrome. The data in our patient are quite similar to those reported in patients with single-nucleotide polymorphism (SNP) of PHACTR1. Obtaining the patient's informed consent, we analyzed a common SNP variation in the rs9349379[G] allele (PHACTR1), which has been reported to be associated with a lower risk of sCAD.
机译：自发性颈动脉解剖（sCAD）是年轻人缺血性中风的主要原因。 sCAD通常涉及多条颈动脉，占sCAD病例总数的13％-28％。但是，有关多个sCAD的因素知之甚少。在这种情况下，一名52岁的男子因头痛而无先兆。有偏头痛先兆的个人病史和类似症状的家族病史。该患者的弟弟在48岁时解剖了动脉瘤并对其左动脉进行了血管内闭塞。我们收治患者的磁共振成像显示右颈内动脉（ICA）出现高强度，没有急性梗塞，磁共振血管造影显示右ICA变窄。然后进行血管造影，显示左ICA和VA以及右ICA的解剖痕迹。该患者未达到任何胶原蛋白血管疾病的主要标准，例如IV型Ehlers-Danlos综合征或Loeys-Dietz综合征。我们患者的数据与PHACTR1的单核苷酸多态性（SNP）患者报告的数据非常相似。获得患者的知情同意后，我们分析了rs9349379 [G]等位基因（PHACTR1）中常见的SNP变异，据报道这与较低的sCAD风险有关。

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