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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Elevated Total White Blood Cell Count With High Blood Glucose Is Associated With Poor Outcome After Ischemic Stroke
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Elevated Total White Blood Cell Count With High Blood Glucose Is Associated With Poor Outcome After Ischemic Stroke

机译：缺血性中风后高血糖与总白细胞计数升高相关的不良结果

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摘要

Increases in total white blood cell (WBC) count and blood glucose level have each been associated with poor outcomes after ischemic stroke. The aim of this study was to determine whether there was an added effect of elevated total WBC count with glucose level on outcome after ischemic stroke. A total of 436 consecutive patients with ischemic stroke who were admitted to Suburban Hospital, Bethesda, MD, between June 2000 and December 2002 were included in this study. Nonfast-ing peripheral WBC count and glucose level were obtained on hospital arrival, along with self- and family member-reported risk factors for stroke and clinical parameters, WBC count and glucose level were dichotomized into 4 groups: increased WBC count with increased glucose level (IW;IG), increased WBC count with normal glucose level (IW;NG), normal WBC count with increased glucose level (NW;IG), and normal WBC count with normal glucose level (NW;NG). Poor outcome was defined as a modified Rankin scale score > 2 at hospital discharge. On univariate analysis, patients with IW;IG (n = 53) had worse outcome (P < .001) than patients with NW;NG (n - 210) or elevations in either factor alone. On multivariate logistic regression analysis, after adjustment for stroke severity and other factors, the odds ratios of poor stroke outcomes were 20 (95% confidence interval [CI] = 3.3-125; P < .001) for the IW:IG group, 3.3 (95% CI = 1.1-14.3; P = .03) for the IW;NG group, and 2.5 (95% CI - 1.1-5.0; P = .03) for the NW;IG group, all compared with the NW:NG group. There may be an added effect of elevated WBC count with hyperglycemia on poor outcome after ischemic stroke. Strict control of inflammatory parameters and glucose may help improve outcome for patients with ischemic stroke.
机译：总白细胞（WBC）计数和血糖水平的增加均与缺血性卒中后不良预后相关。这项研究的目的是确定是否增加总白细胞计数与葡萄糖水平对缺血性卒中后预后的影响。在2000年6月至2002年12月之间，共有436名连续缺血性中风患者被纳入贝塞斯达市贝德斯达市郊区医院收治。住院时获得非空腹外周血白细胞计数和血糖水平，以及自我和家庭成员报告的中风危险因素和临床参数，将白细胞计数和血糖水平分为四组：白细胞计数增加和血糖水平升高（IW; IG），血糖水平正常（IW; NG）的白细胞计数增加，血糖水平升高的正常WBC计数（NW; IG）和血糖水平正常（NW; NG）的正常WBC计数。结果差定义为出院时改良的Rankin量表评分> 2。单因素分析显示，IW; IG患者（n = 53）较NW; NG患者（n-210）或单独升高任一因素均具有更差的预后（P <.001）。在多元逻辑回归分析中，对卒中严重程度和其他因素进行校正后，IW：IG组卒中不良预后的比值比为20（95％置信区间[CI] = 3.3-125; P <.001），为3.3 IW; NG组（95％CI = 1.1-14.3; P = .03），NW; IG组为2.5（95％CI-1.1-5.0; P = .03），均与NW相比： NG组。 WBC计数升高伴有高血糖可能对缺血性中风后不良预后产生附加影响。严格控制炎症参数和葡萄糖可能有助于改善缺血性中风患者的预后。

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