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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Polymorphisms of IL-lbeta, IL-lRa, and TNF-a Genes: A Nested Case-Control Study of Their Association With Risk for Stroke
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Polymorphisms of IL-lbeta, IL-lRa, and TNF-a Genes: A Nested Case-Control Study of Their Association With Risk for Stroke

机译：IL-1β，IL-1Ra和TNF-a基因的多态性：与卒中风险相关的巢式病例对照研究

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Certain alleles of cytokine genes interleukin-1 beta (IL-1beta), interleukin-1 receptor antagonist (IL-lRa), and tumor necrosis factor alpha (TNF-a) are correlated with increased production of the proteins. The aim of this study was to investigate polymorphisms of these genes and their possible correlation with the development of stroke. This matched case-control study was nested within the population-based Vasterbotten Intervention Program (VIP) cohort and the Northern Sweden World Health Organization MONICA (Multinational Mom'toring of Trends and Determinants in Cardiovascular Diseases) cohort, based on individuals who were free from cardiovascular events when the cohorts were established. After an average period of 34.1 months, 113 individuals developed stroke and to each case 2 individuals not suffering from cardiovascular events were matched to serve as controls. Polymer-ase chain reaction amplification was used to analyze genetic polymorphisms. There was no association between polymorphic sites of the IL-1beta and IL-lRa genes and stroke. Carriage of haplotype A2~+IL-lbeta/A2~+IL-lRa was significantly increased in normotensive cases (23.1%) compared with normotensive controls (8.9%) (odds ratio [OR] = 3.07; P = .045). In hypertensive male cases, there was an association between the A1A1 genotype of TNF-a and risk of stroke (OR = 2.46; P = .034). Our findings indicate an association between allele Al of the TNF-a Ncol polymorphism and stroke in hypertensive male cases, as well as an association between haplotype A2~+IL-lbeta/A2~+IL-lRa and stroke in normotensive cases.
机译：细胞因子基因白介素-1β（IL-1beta），白介素-1受体拮抗剂（IL-1Ra）和肿瘤坏死因子α（TNF-a）的某些等位基因与蛋白质产量的增加有关。这项研究的目的是研究这些基因的多态性及其与中风发展的可能关系。这项匹配的病例对照研究被嵌套在以人群为基础的Vasterbotten干预计划（VIP）队列和北瑞典世界卫生组织MONICA（心血管疾病趋势和决定因素的跨国监测）队列中，该人群基于队列建立时的心血管事件。平均34.1个月后，有113名患者发生了中风，每例均由2名未患有心血管事件的患者作为对照。聚合酶链反应扩增用于分析遗传多态性。 IL-1β和IL-1Ra基因的多态性位点与中风之间没有关联。与血压正常对照组（8.9％）相比，血压正常组（23.1％）的单倍型A2〜+IL-1β/ A2〜+ IL-1Ra的携带显着增加（赔率[OR] = 3.07; P = .045）。在高血压男性病例中，TNF-α的A1A1基因型与中风风险之间存在关联（OR = 2.46; P = .034）。我们的发现表明，在高血压男性病例中，TNF-αNcol多态性等位基因A1与卒中之间存在关联，在血压正常的病例中，单倍型A2〜+IL-1β/ A2〜+ IL-1Ra与卒中之间存在关联。

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