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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Glial and Axonal Body Fluid Biomarkers Are Related to Infarct Volume, Severity, and Outcome
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Glial and Axonal Body Fluid Biomarkers Are Related to Infarct Volume, Severity, and Outcome

机译：胶质和轴突体液生物标志物与梗死体积，严重程度和结果相关

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摘要

Body fluid biomarkers of central nervous system damage may help improve the prognostic and diagnostic accuracy in ischemic stroke. We studied 53 patients. Stroke severity and outcome was rated using the National Institutes of Health Stroke Scale and modified Rankin scale. Ferritin, S100B, and NfH were measured in cerebrospinal fluid (CSF) and serum. Infarct volume was calculated from T2W images. CSF S100B (median 1.00 ng/mL) and CSF ferritin (10.0 ng/mL) levels were elevated in patients with stroke compared with control subjects (0.62 ng/mL, P < .0001; 2.34 ng/mL, P < .0001). Serum S100B (0.09 ng/mL) was higher in patients with stroke compared with control subjects (0.01 ng/mL). CSF S100B levels were higher in patients with a cardioembolic stroke (2.88 ng/mL) than in those with small-vessel disease (0.89 ng/mL, P < .05). CSF S100B levels correlated with the National Institutes of Health Stroke Scale score on admission (R = 0.56, P < .01) and the stroke volume (R = 0.44, P = .01). CSF S100B and NfH-SMI35 levels correlated with outcome on the modified Rankin scale. CSF S100B levels were related to stroke severity and infarct volume and highest in cardioembolic stroke.
机译：中枢神经系统损害的体液生物标志物可能有助于改善缺血性中风的预后和诊断准确性。我们研究了53例患者。使用国立卫生研究院卒中量表和改良的兰金量表对卒中严重程度和预后进行评估。在脑脊液（CSF）和血清中测量铁蛋白，S100B和NfH。从T2W图像计算梗死体积。与对照组相比，卒中患者的CSF S100B（中位数1.00 ng / mL）和CSF铁蛋白（10.0 ng / mL）水平升高（0.62 ng / mL，P <.0001; 2.34 ng / mL，P <.0001） 。中风患者的血清S100B（0.09 ng / mL）高于对照组（0.01 ng / mL）。心脏栓塞性卒中患者的CSF S100B水平（2.88 ng / mL）高于小血管疾病患者（0.89 ng / mL，P <.05）。脑脊液S100B水平与入院时美国国立卫生研究院卒中量表评分（R = 0.56，P <.01）和卒中量（R = 0.44，P = .01）相关。 CSF S100B和NfH-SMI35水平与改良的Rankin量表的结果相关。脑脊液S100B水平与卒中严重程度和梗死体积有关，在心脏栓塞性卒中中最高。

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