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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Association of Apolipoprotein E Gene Polymorphism With Ischemic Stroke Involving Large-Vessel Disease and Its Relation to Serum Lipid Levels
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Association of Apolipoprotein E Gene Polymorphism With Ischemic Stroke Involving Large-Vessel Disease and Its Relation to Serum Lipid Levels

机译：载脂蛋白E基因多态性与涉及大血管疾病的缺血性卒中的关系及其与血脂水平的关系

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摘要

A relationship between apolipoprotein E (Apo E) genotype and stroke was previously suggested, but with inconsistent results. We investigated the relationships among serum lipid levels, Apo E alleles and genotypes, and stroke risk factors in 216 stroke patients and 282 age- and sex-matched controls. Fasting blood samples were collected for total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipopro-tein cholesterol (HDL-C), and triglyceride level determination and for genomic DNA extraction. Apo e was genotyped by polymerase chain reaction-restriction fragment length polymorphism (Cfo I) analysis. Increasing levels of total cholesterol, LDL-C, HDL-C, and triglycerides were associated with elevated stroke risk and was more pronounced in Apo E4-carrying subjects than in E3- and/or E2-carrying subjects. Apo e3 was significantly lower (0.546 vs 0.736; P < .001), whereas Apo e4 was higher in the stroke patients (0.370 vs 0.181; P < .001); Apo el was present at low but comparable frequencies. The prevalence of E3/E3 was lower and that of E4-containing phenotypes (E3/E4 and homozygous E4/E4) was higher in the stroke patients. The prevalence of the E4-containing phenotypes were significantly higher in ischemic versus hemor-rhagic (P < .001) and in small-vessel versus large-vessel stroke cases (P < .001), and was associated with increased need for statin drugs (P = .040). Logistic regression models, after adjusting for potentially confounding variables including lipid profile, age, and sex, showed an significant association of apo e4 genotype with risk of stroke (P = .033). Our findings indicate that Apo e4 is an independent risk factor associated with an altered lipid profile in this study population.
机译：先前曾提出载脂蛋白E（Apo E）基因型与中风之间的关系，但结果不一致。我们调查了216名中风患者和282名年龄和性别匹配的对照者的血脂水平，Apo E等位基因和基因型与中风危险因素之间的关系。采集空腹血样，用于总胆固醇，低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL-C）和甘油三酸酯含量的测定以及基因组DNA提取。通过聚合酶链反应-限制性片段长度多态性（Cfo I）分析对Apo e进行基因分型。总胆固醇，LDL-C，HDL-C和甘油三酸酯水平的升高与中风风险升高相关，并且在携带Apo E4的受试者中比在携带E3和/或E2的受试者中更为明显。脑卒中患者的Apo e3显着较低（0.546比0.736; P <.001），而中风患者的Apo e4较高（0.370 vs 0.181; P <.001）; Apoel的出现频率较低但可比。脑卒中患者中E3 / E3的患病率较低，而含E4的表型（E3 / E4和纯合E4 / E4）患病率较高。缺血性出血性出血相比，出血性出血性出血的表型患病率高（P <.001），小血管和大血管卒中病例的含E4表型患病率（P <.001），与他汀类药物的需求增加有关（P = .040）。在调整了可能混杂的变量（包括脂质谱，年龄和性别）后，逻辑回归模型显示apo e4基因型与中风风险之间存在显着相关性（P = .033）。我们的发现表明，Apo e4是与该研究人群中脂质谱改变相关的独立危险因素。

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