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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Recurrent Orthostatic Global Amnesia in a Patient with Postoperative Hyperfibrinogenemia
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Recurrent Orthostatic Global Amnesia in a Patient with Postoperative Hyperfibrinogenemia

机译：术后高纤维蛋白原血症患者反复体位性整体失忆症

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Transient global amnesia (TGA) is characterized by sudden, temporary dysfunction of antegrade and recent retrograde memory without other neurologic deficits. Although there is sometimes a precipitating event, the origin of TGA remains controversial. We encountered a patient who developed recurrent TGA when upright, in whom the symptom promptly and regularly resolved when supine. Symptoms began about a week after cardiac surgery concurrent with marked hyperfibrinogenemia and acceleration of the erythrocyte sedimentation rate, and abated without recurrence when these laboratory abnormalities were ameliorated by anticoagulant and corticosteroid therapy. Diagnostic studies, including temporal artery biopsy and cerebral angiography, disclosed no anatomic vascular pathology. This is the first report of TGA associated with postoperative inflammation in which amnesia was provoked by orthostatic positioning. In conclusion, these observations implicate ischemia caused by hemodynamic vascular insufficiency as a possible cause of TGA.
机译：暂时性全球性健忘症（TGA）的特征是突然，暂时的顺行功能障碍和最近的逆行记忆，而没有其他神经系统缺陷。尽管有时会发生一些突发事件，但TGA的起源仍存在争议。我们遇到一名在直立时发展为复发性TGA的患者，仰卧时症状迅速并有规律地缓解。心脏手术后约一周开始出现症状，同时伴有明显的高纤维蛋白原血症和红血球沉降速率加快，并且通过抗凝和皮质类固醇激素疗法改善了这些实验室异常后，症状消失且无复发。诊断研究，包括颞动脉活检和脑血管造影，未发现解剖血管病理学。这是TGA与术后炎症相关的首次报道，其中体位性定位引起了健忘症。总之，这些观察结果暗示由血流动力学血管供血不足引起的局部缺血可能是TGA的可能原因。

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