...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Factors Associated with the Steep Increase in Late Midlife Stroke Occurrence among US Men
【24h】

Factors Associated with the Steep Increase in Late Midlife Stroke Occurrence among US Men

机译：美国男性中年末中风发生率急剧增加的相关因素

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Data on recent stroke prevalence rates among middle-aged men in the United States indicate that men aged 55 to 64 years are 3 times more likely than men aged 45 to 54 years to have experienced a stroke. We aimed to determine potential risk factors that may contribute to this steep increase in late midlife stroke occurrence. Methods: We analyzed the National Health and Nutrition Examination Survey 1999 to 2004 data sets, assessing stroke prevalence, predictors of stroke occurrence, and vascular risk factors in men across their midlife years. Results: Crudely, higher glycohemoglobin, history of hypertension, history of diabetes, and history of coronary artery disease significantly predicted stroke in 45- to 54-and 54-to 64-year-old men. Significant stroke risk factors unique to each age group were non-white race, lower ankle-brachial pulsatility index, and occurrence of recent severe headache in the 45- to 54-year age group, whereas elevated serum homocysteine (HCY) level predicted stroke in those aged 55 to 64 years. In multivariable regression analysis, lower ankle-brachial pulsatility index (odds ratio [OR] 1.69,95% confidence interval [CI] 1.47-1.83, P < .001) and recent severe headache (OR 5.12, 95% CI 1.3-20.1, P = .019) were the only independent predictors of stroke in the 45- to 54-year age group, whereas only elevated HCY predicted stroke in the 55-to 64-year age group (OR 1.708,95% CI -1.103-2.643, P = .0163). Conclusion: Elevated serum HCY level is the sole independent predictor of stroke among men aged 55 to 64 years in the United States. Further study to assess the efficacy of HCY-lowering treatment in mitigating a steep increase in late midlife stroke occurrence among men may be warranted.
机译：背景：美国中年男性最近的中风患病率数据表明，年龄在55至64岁之间的男性发生中风的可能性是45岁至54岁之间的男性的3倍。我们旨在确定可能导致中年末中风急剧增加的潜在危险因素。方法：我们分析了1999年至2004年的国家健康和营养调查数据集，评估了中年男性的中风患病率，中风发生的预测因子和血管危险因素。结果：严重的糖化血红蛋白升高，高血压病史，糖尿病史和冠心病史显着预测了45岁至54岁和54岁至64岁男性的中风。每个年龄组独特的重要中风危险因素是非白人种族，较低的踝臂搏动指数以及45至54岁年龄组中最近发生的严重头痛，而血清高半胱氨酸（HCY）水平升高可预测中风。 55至64岁的人。在多变量回归分析中，较低的踝臂搏动指数（几率[OR] 1.69,95％置信区间[CI] 1.47-1.83，P <.001）和近期出现的严重头痛（OR 5.12，95％CI 1.3-20.1， P = .019）是45至54岁年龄组中卒中的唯一独立预测因子，而55至64岁年龄组中只有HCY预测的中风升高（OR 1.708,95％CI -1.103-2.643 ，P = .0163）。结论：在美国55岁至64岁的男性中，血清HCY水平升高是卒中的唯一独立预测因子。可能需要进行进一步的研究，以评估降低HCY的治疗在缓解男性中晚期中风后期急剧增加方面的功效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号