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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Is p-Thalassemia Trait a Protective Factor Against Ischemic Cerebrovascular Accidents?
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Is p-Thalassemia Trait a Protective Factor Against Ischemic Cerebrovascular Accidents?

机译：p-地中海贫血特质是否可预防缺血性脑血管意外？

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摘要

Objective: In this research, we sought to determine the association between P-thalassemia trait and ischemic cerebrovascular accident (CVA). Methods: In a case-control study, 148 patients with thromboembolic cerebrovascular events were evaluated for the presence of hypertension, diabetes mellitus, hyperlipidemia, and p-thalassemia trait. A total of 156 age- and sex-matched patients with no cardiac or cerebrovascular diseases, serving as the control group, were also investigated for the above-mentioned risk factors. Results: We found that 6.1% of patients with ischemic CVA and 12.2% of the control group had P-thalassemia trait (P = .066). In male patients, the negative association between ischemic CVA and presence of p-thalassemia trait was significant (P = .008). In patients, the prevalence of hypertension was also significantly different between those with and without P-thalassemia trait (P = .01); those with p-thalassemia trait had a lower mean blood pressure than those without the trait. Conclusion:p-Thalassemia trait may have a protective effect against ischemic CVA that might be caused by the lower arterial blood pressure observed in those with this trait.
机译：目的：在这项研究中，我们试图确定P地中海贫血性状与缺血性脑血管意外（CVA）之间的关系。方法：在一项病例对照研究中，对148例血栓栓塞性脑血管事件的患者进行了高血压，糖尿病，高脂血症和p地中海贫血特征的评估。作为对照组，共调查了156例无心脏或脑血管疾病的年龄和性别匹配的患者的上述危险因素。结果：我们发现6.1％的缺血性CVA患者和12.2％的对照组具有P地中海贫血特征（P = .066）。在男性患者中，缺血性CVA与p地中海贫血特征的存在呈负相关（P = .008）。在患者中，患有和不患有P地中海贫血特征的人的高血压患病率也显着不同（P = 0.01）;具有地中海贫血特征的人的平均血压低于没有地中海贫血特征的人。结论：p-地中海贫血性状可能对缺血性CVA具有保护作用，可能是由于该病患者的动脉血压降低所致。

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