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首页> 外文期刊>Clinical drug investigation >Monophasic Estrogen-Progestogen Therapy and Sexuality in Postmenopausal Women
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Monophasic Estrogen-Progestogen Therapy and Sexuality in Postmenopausal Women

机译：绝经后妇女的单相雌激素-孕激素治疗和性行为

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Objective: This study aimed to evaluate the effects of monophasic estrogen-progestogen therapy on the sexuality and climacteric symptoms of postmenopausal women. Patients and methods: A prospective, randomised, double-blind, crossover, placebo-controlled, single-centre study was carried out over a total of 12 consecutive months in 40 postmenopausal women with an intact uterus who had no contraindications to hormone therapy. Patients received 17p-estradiol 2mg in combination with norethisterone acetate lmg (Cliane~R) daily for 6 months or one placebo tablet daily for 6 months. The tablets were identical in appearance. After 6 months, the groups were crossed over and the patients were followed up for another 6 months. The groups were homogenous with respect to age, height, bodyweight, body mass index and race. For the statistical analysis, the group receiving hormone therapy was referred to as group A and the placebo group was designated group B, irrespective of the placebo/hormone therapy sequence. Results: In group A there were fewer hot flashes (F = 22.85, p < 0.01) and an improvement in sexual interest (F = 5.55, p < 0.05). The sequence in which the medication was received resulted in a statistically significant difference with respect to dyspareunia (F = 9.65, p < 0.01) and satisfaction with the duration of penetration (F = 6.58, p < 0.05). In the intrapatient analysis of variation with respect to orgasmic capability and the presence of dialogue with partner regarding the couple's sexual life, whether the placebo was taken prior to or following hormone therapy was significant (F = 17.12, p < 0.001 and F = 7.10, p < 0.05, respectively). Conclusions: Monophasic estrogen-progestogen therapy has a beneficial effect on sexuality and on hot flashes in postmenopausal women.
机译：目的：本研究旨在评估单相雌激素-孕激素治疗对绝经后妇女性行为和更年期症状的影响。患者和方法：前瞻性，随机，双盲，交叉，安慰剂对照，单中心研究共对40例子宫完整且没有激素治疗禁忌症的绝经后妇女进行了连续12个月的研究。患者每天接受17mg雌二醇2mg联合醋酸炔诺酮1mg（Cliane〜R），共6个月，或每天服用一种安慰剂片剂，共6个月。片剂外观相同。 6个月后，各组进行交叉，对患者再随访6个月。各组在年龄，身高，体重，体重指数和种族方面均相同。为了进行统计分析，与安慰剂/激素治疗顺序无关，接受激素治疗的组称为A组，安慰剂组称为B组。结果：A组潮热较少（F = 22.85，p <0.01），并且性兴趣得到改善（F = 5.55，p <0.05）。服用药物的顺序导致性交困难（F = 9.65，p <0.01）和对渗透持续时间的满意度（F = 6.58，p <0.05）在统计学上有显着差异。在对性高潮能力变化的门诊患者分析以及与伴侣之间关于夫妻的性生活的对话中，安慰剂是否在激素治疗之前或之后服用是很重要的（F = 17.12，p <0.001和F = 7.10，分别为p <0.05）。结论：单相雌激素-孕激素疗法对绝经后妇女的性行为和潮热有有益作用。

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