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首页> 外文期刊>Journal of studies on alcohol >Different components of opioid-substitution treatment predict outcomes of patients with and without a parent with substance-use problems.
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Different components of opioid-substitution treatment predict outcomes of patients with and without a parent with substance-use problems.

机译：阿片类药物替代治疗的不同组成部分可预测有无药物滥用父母的患者的结局。

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OBJECTIVE: The aim of this study was to determine how the treatment needs and outcomes of polysubstance-using patients entering opioid-substitution treatment (OST) may be affected if the patient had a parent with substance-use problems. METHOD: This prospective observational study examined outcomes of 255 patients (97% male) entering OST at eight clinics in the Veterans Health Administration. Self-reported substance-use outcomes in the first year of treatment were compared between patients with (n = 121) and without (n = 134) a parent with substance-use problems. The association between receipt of practice guideline-recommended elements of care and treatment outcome was examined. RESULTS: Parent history-positive patients had greater drug use at 6 months, but by 12 months they had reduced their drug use to the same extent as parent history-negative patients. Ongoing methadone (Dolophine, Methadose) maintenance was associated with improved outcomes of drug use in parent history-negative patients; however, parent history-positive patients who ended methadone maintenance reduced drug use as much as those who continued treatment. The association between treatment received and outcome differed in these populations. In parent history-negative patients, reduced severity of substance use at 1 year was predicted solely by receiving methadone for a greater number of days. In parent history-positive patients, reduced severity of substance use was predicted by receiving methadone for fewer days, by greater satisfaction with and receipt of counseling services, and by lesser tendency for providers to encourage a reduction in methadone use. CONCLUSIONS: The importance of counseling and medication components of OST may differ depending on family history. For parent history-negative patients, medication maintenance may be more therapeutically necessary.
机译：目的：本研究的目的是确定如果父母有药物使用问题的患者接受阿片替代治疗（OST）的多药物使用患者的治疗需求和结果如何受到影响。方法：这项前瞻性观察性研究在退伍军人卫生管理局的八家诊所检查了255例进入OST的患者（男性占97％）的结局。比较了有（n = 121）和没有（n = 134）父母有药物使用问题的患者在治疗第一年的自我报告的药物使用结果。检查了实践指南推荐的护理要素与治疗结果之间的关联。结果：父母病史阳性患者在6个月时有更多的药物使用，但到12个月时，他们的药物使用量减少程度与父母病史阴性患者相同。持续的美沙酮（Dolophine，Methadose）维持与父母病史阴性患者的药物使用效果改善相关。但是，终止美沙酮维持治疗的父母病史阳性患者与继续治疗的患者相比，减少了药物使用。在这些人群中，治疗与结果之间的关联有所不同。在父母病史阴性的患者中，仅通过接受美沙酮治疗更多天，就可以预测1年时物质使用的严重性降低。在父母病史呈阳性的患者中，通过减少服用美沙酮的时间，对服务的满意度和接受程度的提高以及提供者鼓励减少美沙酮使用的趋势较小，可以预测药物使用的严重性降低。结论：OST的咨询和药物治疗的重要性可能因家族史而异。对于父母病史阴性的患者，药物治疗可能在治疗上更为必要。

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