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首页> 外文期刊>Journal of studies on alcohol and drugs. >Preliminary Functional MRI Results From a Combined Stop-Signal Alcohol-Cue Task
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Preliminary Functional MRI Results From a Combined Stop-Signal Alcohol-Cue Task

机译：结合停止信号酒精提示任务的初步功能性MRI结果

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Objective: Individuals suffering from alcohol use disorders tend to show impairments in inhibitory control, and these deficits may be exacerbated in the presence of craving-inducing alcohol cues. Imbalances between neural reward and control networks can influence the trajectory of alcohol use disorders such that individuals for whom the reward (craving) network strongly overpowers the control (inhibition) network tend to have worse outcomes. Brain activation related to inhibitory control can be examined using the stop-signal task (SST), which requires balancing speed and accuracy in the context of frequent go and infrequent stop stimuli. Further, brain areas related to cue-induced craving can be studied using visual cue tasks comparing neural responses to alcohol and control images. This study aims to explore the interaction of inhibitory control and cue-elicited craving using a single functional neuroimaging task. Method: We developed a novel task involving presentation of alcohol and control cues concurrently with a standard SST paradigm and administered it to 53 heavy drinkers (29 women). Results: Successful response inhibition during alcohol compared to control picture trials was associated with significant activation in anterior cingulate, supplementary motor, and frontal inferior regions, and this activation was differentially related to alcohol use symptom severity across several self-report measures. Conclusions: Results suggest that recruitment of compensatory error detection and inhibitory control resources may be required for successful inhibition in the presence of alcohol cues among more severe drinkers. These preliminary findings support the construct validity of the task and indicate several methodological alterations to the task's design that should be implemented in future studies.
机译：目的：患有饮酒障碍的个体倾向于在抑制控制方面表现出缺陷，在渴望诱导饮酒的情况下，这些缺陷可能会加剧。神经奖励和控制网络之间的不平衡会影响酒精使用障碍的轨迹，因此奖励（渴望）网络大大压倒控制（抑制）网络的人往往会出现较差的结果。可以使用停止信号任务（SST）检查与抑制控制相关的大脑激活，这需要在频繁走动和不频繁的停止刺激的情况下平衡速度和准确性。此外，可以使用视觉提示任务来比较与提示诱发的渴望相关的大脑区域，这些任务将对酒精和控制图像的神经反应进行比较。这项研究旨在探索抑制控制和提示引起的渴望使用单个功能性神经成像任务的相互作用。方法：我们制定了一项新颖的任务，包括与标准的SST范例同时进行酒精和控制提示的呈现，并向53名重度饮酒者（29名女性）进行管理。结果：与对照图片试验相比，酒精中成功的反应抑制与前扣带，辅助运动和额叶下部区域的显着激活有关，并且这种激活与几种自我报告措施中酒精使用症状的严重程度存在差异。结论：结果表明，在酒精信号较严重的饮酒者中，成功地抑制酒精可能需要补充补偿性错误检测和抑制性控制资源。这些初步发现支持任务的结构正确性，并指出应在以后的研究中对任务设计进行一些方法上的更改。

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