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首页> 外文期刊>Journal of studies on alcohol and drugs. >Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans.
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Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans.

机译：急性莫达非尼对依赖甲基苯丙胺的人的注意力和抑制控制的影响。

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OBJECTIVE: Individuals who are methamphetamine dependent exhibit higher rates of cognitive dysfunction than healthy people who do not use methamphetamine, and this dysfunction may have a negative effect on the success of behavioral treatments for the disorder. Therefore, a medication that improves cognition, such as modafinil (Provigil), may serve as a useful adjunct to behavioral treatments for methamphetamine dependence. Although cognitive-enhancing effects of modafinil have been reported in several populations, little is known about the effects of modafinil in methamphetamine-dependent individuals. We thus sought to evaluate the effects of modafinil on the cognitive performance of methamphetamine-dependent and healthy individuals. METHOD: Seventeen healthy subjects and 24 methamphetamine- dependent subjects participated in this randomized, double-blind, placebo-controlled, crossover study. Effects of modafinil (200 mg, single oral dose) were assessed on participants' performance on tests of inhibitory control, working memory, and processing speed/attention. RESULTS: Across subjects, modafinil improved performance on a test of sustained attention, with no significant improvement on any other cognitive tests. However, within the methamphetamine-dependent group only, participants with a high baseline frequency of methamphetamine use demonstrated a greater effect of modafinil on tests of inhibitory control and processing speed than those participants with low baseline use of methamphetamine. CONCLUSIONS: Although modafinil produced limited effects across all participants, methamphetamine-dependent participants with a high baseline use of methamphetamine demonstrated significant cognitive improvement on modafinil relative to those with low baseline methamphetamine use. These results add to the findings from a clinical trial that suggested that modafinil may be particularly useful in methamphetamine-dependent subjects who use the drug frequently.
机译：目的：依赖甲基苯丙胺的个体比不使用甲基苯丙胺的健康人表现出更高的认知功能障碍，这种功能障碍可能对该疾病的行为治疗成功产生负面影响。因此，提高认知度的药物，例如莫达非尼（Provigil），可以作为对甲基苯丙胺依赖性行为治疗的有用辅助手段。尽管已在一些人群中报告了莫达非尼的认知增强作用，但对莫达非尼在依赖甲基苯丙胺的个体中的作用知之甚少。因此，我们寻求评估莫达非尼对甲基苯丙胺依赖性健康人认知能力的影响。方法：17名健康受试者和24名依赖甲基苯丙胺的受试者参加了这项随机，双盲，安慰剂对照，交叉研究。评估莫达非尼（200 mg，单次口服剂量）对参与者的抑制控制，工作记忆和加工速度/注意力测试的表现。结果：在所有受试者中，莫达非尼在持续关注力测试中的表现均得到改善，而其他认知测试均无显着改善。但是，仅在甲基苯丙胺依赖组中，使用甲基苯丙胺基线频率较高的参与者证明莫达非尼对抑制对照和加工速度测试的影响要比那些使用甲基苯丙胺基线基准较低的参与者更大。结论：尽管莫达非尼在所有参与者中产生的作用有限，但是与甲基苯丙胺基线使用量较低的患者相比，甲基苯丙胺基线使用量较高的依赖甲基苯丙胺的参与者表现出对莫达非尼的显着认知改善。这些结果增加了一项临床试验的发现，该结果表明莫达非尼在频繁使用该药物的甲基苯丙胺依赖性受试者中可能特别有用。

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