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首页> 外文期刊>Journal of submicroscopic cytology and pathology >Distribution of COX-negative mitochondria in myofibers of rats intoxicated with Senna occidentalis seeds.
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Distribution of COX-negative mitochondria in myofibers of rats intoxicated with Senna occidentalis seeds.

机译：塞那番泻叶种子中毒的大鼠肌纤维中COX阴性线粒体的分布。

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摘要

We have described that administration of seeds or parts of the seed of Senna occidentalis (coffee senna) for long periods, induces histochemical changes in the skeletal muscles of hens and rats that are characteristic of a mitochondrial myopathy--as decrease of SDH and COX activity, with some COX negative fibers. In this experimental model of mitochondrial myopathy, as in many human mitochondrial diseases, there is a random distribution of COX negative fibers. Some fibers are completely COX negative while others are partially negative and others are completely positive. In the present work we have studied the distribution of COX negative mitochondria at transmission electron microscopy in skeletal muscle of rats in this experimental myopathy. In myofibers of intoxicated animals the expression of COX was heterogeneous. The histochemical reaction was observed in the internal membrane (more evident in mitochondrial cristae) of all mitochondria of some myofibers, while it was almost absent in other myofibers. In these myofibers the great part of the mitochondria were negative for COX reaction while other ones had a weak expression of this enzyme (dot or focal expression of COX). Our results indicated that the COX mitochondrial activity is heterogeneously impaired in myofibers of rats intoxicated with S. occidentalis. These abnormalities remember those observed in some types of human mitochondrial myopathies.
机译：我们已经描述了长期施用种子或西番莲（番泻叶）种子会诱导母鸡和大鼠骨骼肌的组织化学变化，这是线粒体肌病的特征-SDH和COX活性降低，带有一些COX负纤维。与许多人类线粒体疾病一样，在这种线粒体肌病实验模型中，COX阴性纤维是随机分布的。一些光纤完全是COX阴性的，而另一些则是部分阴性的，而另一些则是完全阳性的。在目前的工作中，我们已经在透射电镜下研究了这种实验性肌病大鼠的COX阴性线粒体在骨骼肌中的分布。在醉酒动物的肌纤维中，COX的表达是异质的。在某些肌纤维的所有线粒体的内膜中观察到组织化学反应（在线粒体cr中更明显），而在其他肌纤维中几乎没有。在这些肌纤维中，线粒体的大部分对COX反应呈阴性，而其他肌纤维对此酶的表达较弱（COX的点或局部表达）。我们的结果表明，在被西方葡萄球菌中毒的大鼠肌纤维中，COX线粒体活性异质性受损。这些异常记住在某些类型的人类线粒体肌病中观察到的异常。

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