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首页> 外文期刊>Journal of submicroscopic cytology and pathology >Amphicrine carcinoma of breast with giant granules: an immunohistochemical, histochemical and ultrastructural study.
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Amphicrine carcinoma of breast with giant granules: an immunohistochemical, histochemical and ultrastructural study.

机译：带有巨大颗粒的乳腺香霉素癌：一项免疫组织化学，组织化学和超微结构研究。

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A moderately differentiated grade 2 invasive ductal carcinoma was diagnosed in the right breast of an 81-year-old woman. The uniform nuclear profiles and moderately abundant granular cytoplasm suggested a neuroendocrine tumour and a Grimelius stain was positive. Neurone specific enolase, synaptophysin and somatostatin stained positively, and casein was interpreted as positive although with some background staining. By electron microscopy, tumour cells possessed desmosomes, tonofibrils, intercellular lumina, lamina and dense granules. Rounded dense granules 160-480 nm in diameter resembled neuroendocrine granules. They were found in both luminal and basal areas. Fewer and much larger ('giant') granules had a rounded profile and were up to 5 microm across. The smaller cytoplasmic granules were mostly Grimelius-positive while giant granules were negative. The smaller granules were also uranaffin-positive, but no uranaffin-positive cytoplasmic giant granules were encountered. Both small and giant granules were observed in lumina, and here both were uranaffin-positive. Intraluminal giant granules had a substructure of small pale lipid-like lacunae, and some had irregular profiles. The exceptional size of these exocrine granules is emphasised, and the nature of both the small and giant granules discussed in this amphicrine carcinoma.
机译：在一名81岁妇女的右乳房中诊断出中度分化的2级浸润性导管癌。均匀的核分布和适度的颗粒状细胞质提示神经内分泌肿瘤，Grimelius染色阳性。神经元特异性烯醇化酶，突触素和生长抑素染色为阳性，酪蛋白被解释为阳性，尽管有一些背景染色。通过电子显微镜观察，肿瘤细胞具有桥粒，扁纤维，细胞间腔，层板和致密颗粒。直径为160-480 nm的圆形致密颗粒类似于神经内分泌颗粒。在管腔和基底区域都发现了它们。数量更少且更大的（“巨型”）颗粒具有圆形轮廓，跨度最大为5微米。较小的细胞质颗粒大多数为革兰氏阳性，而巨大颗粒为阴性。较小的颗粒也具有尿烷蛋白阳性，但未遇到尿烷蛋白阳性的细胞质巨颗粒。在管腔中均观察到小颗粒和大颗粒，此处均为尿石素阳性。管腔内巨大颗粒的亚结构为浅淡的类脂脂质小腔隙，有些具有不规则的轮廓。这些外分泌颗粒的特殊尺寸被强调，并且在该两性霉素癌症中讨论了小颗粒和巨大颗粒的性质。

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