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首页> 外文期刊>Journal of substance abuse treatment >Factors associated with complicated buprenorphine inductions.
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Factors associated with complicated buprenorphine inductions.

机译：与复杂的丁丙诺啡诱导相关的因素。

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摘要

Despite data supporting its efficacy, barriers to implementation of buprenorphine for office-based treatment are present. Complications can occur during buprenorphine inductions, yet few published studies have examined this phase of treatment. To examine factors associated with complications during buprenorphine induction, we conducted a retrospective chart review of the first 107 patients receiving buprenorphine treatment in an urban community health center. The primary outcome, defined as complicated induction (precipitated or protracted withdrawal), was observed in 18 (16.8%) patients. Complicated inductions were associated with poorer treatment retention (than routine inductions) and decreased over time. Factors independently associated with complicated inductions included recent use of prescribed methadone, recent benzodiazepine use, no prior experience with buprenorphine, and a low initial dose of buprenorphinealoxone. Findings from this study and further investigation of patient characteristics and treatment characteristics associated with complicated inductions can help guide buprenorphine treatment strategies.
机译：尽管有数据支持其功效，但存在丁丙诺啡用于办公室治疗的障碍。在丁丙诺啡诱导过程中可能会发生并发症，但是很少有已发表的研究对这一阶段的治疗进行检查。为了检查与丁丙诺啡诱导过程中并发症相关的因素，我们在城市社区卫生中心对前107名接受丁丙诺啡治疗的患者进行了回顾性图表回顾。在18例（16.8％）的患者中观察到了主要结局，定义为复杂的诱导（戒断或长期停药）。复杂的诱导与较差的治疗保留（与常规诱导相比）相关，并且随着时间的推移而下降。与复杂诱导相关的独立因素包括最近使用处方美沙酮，最近使用苯二氮卓，没有使用丁丙诺啡的经验以及丁丙诺啡/纳洛酮的初始剂量低。这项研究的发现以及对与复杂诱导相关的患者特征和治疗特征的进一步研究可以帮助指导丁丙诺啡的治疗策略。

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