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首页> 外文期刊>Journal of substance abuse treatment >Extended-release naltrexone for treatment of alcohol dependence in primary care.
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Extended-release naltrexone for treatment of alcohol dependence in primary care.

机译：缓释纳曲酮用于初级保健中酒精依赖的治疗。

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摘要

The feasibility of using extended-release injectable naltrexone (XR-NTX) to treat alcohol dependence in routine primary care settings is unknown. An open-label, observational cohort study evaluated 3-month treatment retention, patient satisfaction, and alcohol use among alcohol-dependent patients in two urban public hospital medical clinics. Adults seeking treatment were offered monthly medical management (MM) and three XR-NTX injections (380 mg, intramuscular). Physician-delivered MM emphasized alcohol abstinence, medication effects, and accessing mutual help and counseling resources. Seventy-two alcohol-dependent patients were enrolled; 90% (65 of 72) of eligible subjects received the first XR-NTX injection; 75% (49 of 65) initiating treatment received the second XR-NTX injection; 62% (40 of 65), the third. Among the 56% (n = 40) receiving three injections, median drinks per day decreased from 4.1 (95% confidence interval = 2.9-6) at baseline to 0.5 (0-1.7) during Month 3. Extended-release naltrexone delivered in a primary care MM model appears a feasible and acceptable treatment for alcohol dependence.
机译：在常规的初级保健机构中，使用缓释可注射纳曲酮（XR-NTX）治疗酒精依赖的可行性尚不清楚。一项开放标签的观察性队列研究评估了两家城市公立医院医疗诊所中3个月的治疗保留，患者满意度和酒精依赖患者的饮酒情况。向寻求治疗的成年人提供每月医疗管理（MM）和三次XR-NTX注射（380毫克，肌内注射）。医师交付的MM强调戒酒，用药效果以及获得互助和咨询资源。入组72例酒精依赖患者; 90％（72个中的65个）合格受试者接受了首次XR-NTX注射; 75％（65中的49）的开始治疗接受了第二次XR-NTX注射; 62％（65中的40），第三。在接受三剂注射的56％（n = 40）中，每天的中位数饮料从基线时的4.1（95％置信区间= 2.9-6）下降至第3个月的0.5（0-1.7）。初级保健MM模型似乎是一种可行且可接受的酒精依赖治疗方法。

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